TY - JOUR
T1 - Programmed death ligand 1 (PDL-1) expression in triple negative breast cancer cells
T2 - New proposal for a "tumor score" definition
AU - Di Bonito, Maurizio
AU - Scognamiglio, Giosuè
AU - Collina, Francesca
AU - Liguori, Giuseppina
AU - Cantile, Monica
AU - Botti, Gerardo
PY - 2016
Y1 - 2016
N2 - Recently, several studies showed that PDL-1 pathway may have a key role in the interaction of tumor cells with host immune response, and PDL-1 expression of tumor cells may serve as a mechanism of adaptive immune resistance. The data available in the literature about PDL-1 immunohistochemical expression in tumor tissues are not uniform, for the use of different antibodies clones and the absence of a standardized operative protocol. In this study we analyzed PDL-1 expression in a series of triple negative breast cancers and defined a standardized protocol suggesting a "tumor score" for its evaluation. Its application on large tumor case series will allow to investigate the real prognostic value of PD-L1.
AB - Recently, several studies showed that PDL-1 pathway may have a key role in the interaction of tumor cells with host immune response, and PDL-1 expression of tumor cells may serve as a mechanism of adaptive immune resistance. The data available in the literature about PDL-1 immunohistochemical expression in tumor tissues are not uniform, for the use of different antibodies clones and the absence of a standardized operative protocol. In this study we analyzed PDL-1 expression in a series of triple negative breast cancers and defined a standardized protocol suggesting a "tumor score" for its evaluation. Its application on large tumor case series will allow to investigate the real prognostic value of PD-L1.
KW - PD-L1
KW - TNBC
KW - Tumor score
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M3 - Article
AN - SCOPUS:85006141718
VL - 9
SP - 11693
EP - 11696
JO - International Journal of Clinical and Experimental Pathology
JF - International Journal of Clinical and Experimental Pathology
SN - 1936-2625
IS - 11
ER -