Recently, several studies showed that PDL-1 pathway may have a key role in the interaction of tumor cells with host immune response, and PDL-1 expression of tumor cells may serve as a mechanism of adaptive immune resistance. The data available in the literature about PDL-1 immunohistochemical expression in tumor tissues are not uniform, for the use of different antibodies clones and the absence of a standardized operative protocol. In this study we analyzed PDL-1 expression in a series of triple negative breast cancers and defined a standardized protocol suggesting a "tumor score" for its evaluation. Its application on large tumor case series will allow to investigate the real prognostic value of PD-L1.
|Number of pages||4|
|Journal||International Journal of Clinical and Experimental Pathology|
|Publication status||Published - 2016|
- Tumor score
ASJC Scopus subject areas
- Pathology and Forensic Medicine