Programmed ventricular stimulation for risk stratification in the Brugada syndrome: A pooled analysis

Jakub Sroubek, Vincent Probst, Andrea Mazzanti, Pietro Delise, Jesus Castro Hevia, Kimie Ohkubo, Alessandro Zorzi, Jean Champagne, Anna Kostopoulou, Xiaoyan Yin, Carlo Napolitano, David J. Milan, Arthur Wilde, Frederic Sacher, Martin Borggrefe, Patrick T. Ellinor, George Theodorakis, Isabelle Nault, Domenico Corrado, Ichiro WatanabeCharles Antzelevitch, Giuseppe Allocca, Silvia G. Priori, Steven A. Lubitz

Research output: Contribution to journalArticlepeer-review


Background - The role of programmed ventricular stimulation in identifying patients with Brugada syndrome at the highest risk for sudden death is uncertain. Methods and Results - We performed a systematic review and pooled analysis of prospective, observational studies of patients with Brugada syndrome without a history of sudden cardiac arrest who underwent programmed ventricular stimulation. We estimated incidence rates and relative hazards of cardiac arrest or implantable cardioverter-defibrillator shock. We analyzed individual-level data from 8 studies comprising 1312 patients who experienced 65 cardiac events (median follow-up, 38.3 months). A total of 527 patients were induced into arrhythmias with up to triple extrastimuli. Induction was associated with cardiac events during follow-up (hazard ratio, 2.66; 95% confidence interval [CI], 1.44-4.92, P

Original languageEnglish
Pages (from-to)622-630
Number of pages9
Issue number7
Publication statusPublished - Feb 16 2016


  • arrhythmias, cardiac
  • Brugada syndrome
  • death, sudden, cardiac
  • electrophysiology
  • risk assessment

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine


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