Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia

Daniela Galimberti, Bernardo Dell'Osso, Chiara Fenoglio, Chiara Villa, Francesca Cortini, Maria Serpente, Sarah Kittel-Schneider, Johannes Weigl, Maria Neuner, Juliane Volkert, C. Leonhard, David G. Olmes, Juliane Kopf, Claudia Cantoni, Elisa Ridolfi, Carlotta Palazzo, Laura Ghezzi, Nereo Bresolin, A. C. Altamura, Elio ScarpiniAndreas Reif

Research output: Contribution to journalArticle

Abstract

Basing on the assumption that frontotemporal lobar degeneration (FTLD), schizophrenia and bipolar disorder (BPD) might share common aetiological mechanisms, we analyzed genetic variation in the FTLD risk gene progranulin (GRN) in a German population of patients with schizophrenia (n = 271) or BPD (n = 237) as compared with 574 age-, gender- and ethnicity-matched controls. Furthermore, we measured plasma progranulin levels in 26 German BPD patients as well as in 61 Italian BPD patients and 29 matched controls. A significantly decreased allelic frequency of the minor versus the wild-type allele was observed for rs2879096 (23.2 versus 34.2%, P

Original languageEnglish
Article numbere32164
JournalPLoS One
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 10 2012

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Bipolar Disorder
Schizophrenia
Genes
Frontotemporal Lobar Degeneration
Plasmas
genes
nationalities and ethnic groups
gene frequency
alleles
genetic variation
gender
Alleles
schizophrenia
Population

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia. / Galimberti, Daniela; Dell'Osso, Bernardo; Fenoglio, Chiara; Villa, Chiara; Cortini, Francesca; Serpente, Maria; Kittel-Schneider, Sarah; Weigl, Johannes; Neuner, Maria; Volkert, Juliane; Leonhard, C.; Olmes, David G.; Kopf, Juliane; Cantoni, Claudia; Ridolfi, Elisa; Palazzo, Carlotta; Ghezzi, Laura; Bresolin, Nereo; Altamura, A. C.; Scarpini, Elio; Reif, Andreas.

In: PLoS One, Vol. 7, No. 4, e32164, 10.04.2012.

Research output: Contribution to journalArticle

Galimberti, D, Dell'Osso, B, Fenoglio, C, Villa, C, Cortini, F, Serpente, M, Kittel-Schneider, S, Weigl, J, Neuner, M, Volkert, J, Leonhard, C, Olmes, DG, Kopf, J, Cantoni, C, Ridolfi, E, Palazzo, C, Ghezzi, L, Bresolin, N, Altamura, AC, Scarpini, E & Reif, A 2012, 'Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia', PLoS One, vol. 7, no. 4, e32164. https://doi.org/10.1371/journal.pone.0032164
Galimberti, Daniela ; Dell'Osso, Bernardo ; Fenoglio, Chiara ; Villa, Chiara ; Cortini, Francesca ; Serpente, Maria ; Kittel-Schneider, Sarah ; Weigl, Johannes ; Neuner, Maria ; Volkert, Juliane ; Leonhard, C. ; Olmes, David G. ; Kopf, Juliane ; Cantoni, Claudia ; Ridolfi, Elisa ; Palazzo, Carlotta ; Ghezzi, Laura ; Bresolin, Nereo ; Altamura, A. C. ; Scarpini, Elio ; Reif, Andreas. / Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia. In: PLoS One. 2012 ; Vol. 7, No. 4.
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