Progress in Alzheimer's disease

Research output: Contribution to journalArticlepeer-review

Abstract

After more than one century from Alois Alzheimer and Gaetano Perusini's first report, progress has been made in understanding the pathogenic steps of Alzheimer's disease (AD), as well as in its early diagnosis. This review discusses recent findings leading to the formulation of novel criteria for diagnosis of the disease even in a preclinical phase, by using biological markers. In addition, treatment options will be discussed, with emphasis on new disease-modifying compounds and future trial design suitable to test these drugs in an early phase of the disease.

Original languageEnglish
Pages (from-to)201-211
Number of pages11
JournalJournal of Neurology
Volume259
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Alzheimer's disease
  • Amyloid
  • Biomarkers
  • Diagnosis
  • Disease-modifying drugs
  • Genetics
  • Inflammation
  • Tau

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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