Progress in the methodological strategies for the detection in real samples of desmosine and isodesmosine, two biological markers of elastin degradation

Simona Viglio, Laura Annovazzi, Maurizio Luisetti, Jan Stolk, Begoña Casado, Paolo Iadarola

Research output: Contribution to journalArticlepeer-review

Abstract

Desmosines are crosslinking amino acids unique to mature elastin in humans. Owing to this unicity, they have been discussed as potentially attractive indicators of connective tissue disorders whose clinical manifestations are mostly the result of elastin degradation. This review covers advances in immunochemical, chromatographic, and electrophoretic procedures applied in the last 25 years to detect and quantitate these crosslinks in a variety of biological samples. Recent applications of CE with LIF detection (CE-LIF) for investigating the content of desmosines in different fluids will also be discussed.

Original languageEnglish
Pages (from-to)202-213
Number of pages12
JournalJournal of Separation Science
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 2007

Keywords

  • Biological fluids
  • Biomarkers
  • Desmosine
  • Isodesmosine

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Chemical Engineering(all)
  • Filtration and Separation

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