Progress report on the palliative therapy of 100 patients with neoplastic effusions by intracavitary low-dose interleukin-2

Paolo Lissoni, Mario Mandalà, Giuseppe Curigliano, Gianluigi Ferretti, Cecilia Moro, Antonio Ardizzoia, Fabio Malugani, Gabriele Tancini, Elisabetta Tisi, Carlo Arrigoni, Sandro Barni

Research output: Contribution to journalArticle

Abstract

Objective: Several cytokines, particularly IL-2 and interferons, are thought to be effective in the palliative therapy of neoplastic effusions. We report on the activity and toxicity of intracavitary administration of low-dose IL-2 in a case series of 100 cancer patients with neoplastic effusions. Methods: One hundred patients with advanced solid tumors and neoplastic effusions underwent IL-2 intracavitary injection as first-line treatment. The most common sites of fluid accumulation were pleura (n = 68), peritoneum (n = 21) and pericardium (n = 11). Breast cancer, lung cancer and mesothelioma were the most frequent neoplasms in our series. One cycle consisted of intracavitary IL-2 at 6,000,000 IU on days 1 and 7. Results: According to Paladine's criteria, an objective clinical response was achieved in 72% (complete response in 27% and partial response in 45%), with a median duration of 5 months (range: 1-11 months). The peritoneum was the least responsive site for neoplastic effusion reduction. IL-2 intracavitary injection was well tolerated in all patients; the only toxicity observed was fever >38°C in 6% of the patients. Conclusion: This study shows that intracavitary injection of IL-2 represents a feasible, well-tolerated and effective therapy of neoplastic fluid accumulation. Further studies are needed in order to compare the effectiveness of intracavitary IL-2 with other standard treatments.

Original languageEnglish
Pages (from-to)308-312
Number of pages5
JournalOncology
Volume60
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Interleukin-2
  • Intracavitary therapy
  • Neoplastic effusions
  • Palliative treatment

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Lissoni, P., Mandalà, M., Curigliano, G., Ferretti, G., Moro, C., Ardizzoia, A., Malugani, F., Tancini, G., Tisi, E., Arrigoni, C., & Barni, S. (2001). Progress report on the palliative therapy of 100 patients with neoplastic effusions by intracavitary low-dose interleukin-2. Oncology, 60(4), 308-312. https://doi.org/10.1159/000058525