Progression of activity and structural changes in the anterior cingulate cortex during remote memory formation

Massimiliano Aceti, Gisella Vetere, Giovanni Novembre, Leonardo Restivo, Martine Ammassari-Teule

Research output: Contribution to journalArticlepeer-review

Abstract

The progression of activity and structural changes in the anterior cingulate cortex during remote contextual fear memory formation was measured by imaging c-fos expression and dendritic spines following retrieval tests administered at six post-training time points (days 1, 5, 7, 14, 21, 36). Here we report that conditioned mice exhibit robust freezing at each time point. C-fos expression starts to augment on day 5, showing a monotonic increase over the successive time points, and then stabilized in relation to the higher freezing scores. The first significant increase in mean spine density emerges on day 7. By day 14, the net number of spines remained stable, yet the distribution of single neuron spine density becomes progressively more homogeneous. Our findings reveal that activity changes precede structural remodeling of neurons in the neocortex while remodeling coherence develops gradually in cortical neuron ensembles.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalNeurobiology of Learning and Memory
Volume123
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Dendritic spine density
  • Neocortex
  • Remodeling coherence
  • Remote memory

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

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