Abstract
The progression of activity and structural changes in the anterior cingulate cortex during remote contextual fear memory formation was measured by imaging c-fos expression and dendritic spines following retrieval tests administered at six post-training time points (days 1, 5, 7, 14, 21, 36). Here we report that conditioned mice exhibit robust freezing at each time point. C-fos expression starts to augment on day 5, showing a monotonic increase over the successive time points, and then stabilized in relation to the higher freezing scores. The first significant increase in mean spine density emerges on day 7. By day 14, the net number of spines remained stable, yet the distribution of single neuron spine density becomes progressively more homogeneous. Our findings reveal that activity changes precede structural remodeling of neurons in the neocortex while remodeling coherence develops gradually in cortical neuron ensembles.
| Original language | English |
|---|---|
| Pages (from-to) | 67-71 |
| Number of pages | 5 |
| Journal | Neurobiology of Learning and Memory |
| Volume | 123 |
| DOIs | |
| Publication status | Published - Sep 1 2015 |
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Keywords
- Dendritic spine density
- Neocortex
- Remodeling coherence
- Remote memory
ASJC Scopus subject areas
- Behavioral Neuroscience
- Cognitive Neuroscience
- Experimental and Cognitive Psychology
Cite this
Progression of activity and structural changes in the anterior cingulate cortex during remote memory formation. / Aceti, Massimiliano; Vetere, Gisella; Novembre, Giovanni; Restivo, Leonardo; Ammassari-Teule, Martine.
In: Neurobiology of Learning and Memory, Vol. 123, 01.09.2015, p. 67-71.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Progression of activity and structural changes in the anterior cingulate cortex during remote memory formation
AU - Aceti, Massimiliano
AU - Vetere, Gisella
AU - Novembre, Giovanni
AU - Restivo, Leonardo
AU - Ammassari-Teule, Martine
PY - 2015/9/1
Y1 - 2015/9/1
N2 - The progression of activity and structural changes in the anterior cingulate cortex during remote contextual fear memory formation was measured by imaging c-fos expression and dendritic spines following retrieval tests administered at six post-training time points (days 1, 5, 7, 14, 21, 36). Here we report that conditioned mice exhibit robust freezing at each time point. C-fos expression starts to augment on day 5, showing a monotonic increase over the successive time points, and then stabilized in relation to the higher freezing scores. The first significant increase in mean spine density emerges on day 7. By day 14, the net number of spines remained stable, yet the distribution of single neuron spine density becomes progressively more homogeneous. Our findings reveal that activity changes precede structural remodeling of neurons in the neocortex while remodeling coherence develops gradually in cortical neuron ensembles.
AB - The progression of activity and structural changes in the anterior cingulate cortex during remote contextual fear memory formation was measured by imaging c-fos expression and dendritic spines following retrieval tests administered at six post-training time points (days 1, 5, 7, 14, 21, 36). Here we report that conditioned mice exhibit robust freezing at each time point. C-fos expression starts to augment on day 5, showing a monotonic increase over the successive time points, and then stabilized in relation to the higher freezing scores. The first significant increase in mean spine density emerges on day 7. By day 14, the net number of spines remained stable, yet the distribution of single neuron spine density becomes progressively more homogeneous. Our findings reveal that activity changes precede structural remodeling of neurons in the neocortex while remodeling coherence develops gradually in cortical neuron ensembles.
KW - Dendritic spine density
KW - Neocortex
KW - Remodeling coherence
KW - Remote memory
UR - http://www.scopus.com/inward/record.url?scp=84930640246&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930640246&partnerID=8YFLogxK
U2 - 10.1016/j.nlm.2015.05.003
DO - 10.1016/j.nlm.2015.05.003
M3 - Article
C2 - 26001597
AN - SCOPUS:84930640246
VL - 123
SP - 67
EP - 71
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
SN - 1074-7427
ER -