Progression of Alzheimer disease in Europe

Data from the European ICTUS study

B. Vellas, L. Hausner, L. Frölich, C. Cantet, V. Gardette, E. Reynish, S. Gillette, E. Agüera-Morales, S. Auriacombe, M. Boada, R. Bullock, J. Byrne, V. Camus, A. Cherubini, M. Eriksdotter-Jönhagen, G. B. Frisoni, S. Hasselbalch, R. W. Jones, P. Martinez-Lage, M. O. Rikkert & 17 others M. Tsolaki, P. J. Ousset, F. Pasquier, J. M. Ribera-Casado, A. S. Rigaud, P. Robert, G. Rodriguez, E. Salmon, A. Salva, P. Scheltens, A. Schneider, A. Sinclair, L. Spiru, J. Touchon, D. Zekry, B. Winblad, S. Andrieu

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The clinical progression of Alzheimer disease (AD) was studied in European subjects under treatment with AChE inhibitors (AChE-I) in relation to geographical location over a 2-years period. One thousand three hundred and six subjects from 11 European countries were clustered into 3 regions (North, South, West) and investigated with biannual follow-up over 2 years. Primary outcomes were cognitive, functional and behavioral measures. Caregiver burden, hospital admission and admission to nursing home were also recorded. Participant cognitive function declined non-linearly over time (MMSE: -1.5 pts/first year, -2.5 pts/second year; ADAScog: + 3.5 pts/first year, + 4.8 pts/second year), while the progression of behavioral disturbances (NPI scale) was linear. Neither scale showed regional differences, and progression of the disease was similar across Europe despite different health care systems. Functional decline (ADL, IADL) tended to progress more rapidly in Southern Europe (p=0.09), while progression of caregiver burden (Zarit Burden Interview) was most rapid in Northern Europe (5.6 pts/y, p=0.04). Incidences of hospital admission (10.44, 95%CI: 8.13-12.75, p

Original languageEnglish
Pages (from-to)902-912
Number of pages11
JournalCurrent Alzheimer Research
Volume9
Issue number8
DOIs
Publication statusPublished - 2012

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Alzheimer Disease
Caregivers
Activities of Daily Living
Nursing Homes
Cognition
Disease Progression
Interviews
Delivery of Health Care
Incidence
Therapeutics

Keywords

  • Alzheimer's disease
  • Caregiver burden, hospital admission
  • Clinical course
  • Cognitive
  • Cohort study
  • Dementia
  • Europe
  • Functional
  • Geographical variation
  • NPI

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Vellas, B., Hausner, L., Frölich, L., Cantet, C., Gardette, V., Reynish, E., ... Andrieu, S. (2012). Progression of Alzheimer disease in Europe: Data from the European ICTUS study. Current Alzheimer Research, 9(8), 902-912. https://doi.org/10.2174/156720512803251066

Progression of Alzheimer disease in Europe : Data from the European ICTUS study. / Vellas, B.; Hausner, L.; Frölich, L.; Cantet, C.; Gardette, V.; Reynish, E.; Gillette, S.; Agüera-Morales, E.; Auriacombe, S.; Boada, M.; Bullock, R.; Byrne, J.; Camus, V.; Cherubini, A.; Eriksdotter-Jönhagen, M.; Frisoni, G. B.; Hasselbalch, S.; Jones, R. W.; Martinez-Lage, P.; Rikkert, M. O.; Tsolaki, M.; Ousset, P. J.; Pasquier, F.; Ribera-Casado, J. M.; Rigaud, A. S.; Robert, P.; Rodriguez, G.; Salmon, E.; Salva, A.; Scheltens, P.; Schneider, A.; Sinclair, A.; Spiru, L.; Touchon, J.; Zekry, D.; Winblad, B.; Andrieu, S.

In: Current Alzheimer Research, Vol. 9, No. 8, 2012, p. 902-912.

Research output: Contribution to journalArticle

Vellas, B, Hausner, L, Frölich, L, Cantet, C, Gardette, V, Reynish, E, Gillette, S, Agüera-Morales, E, Auriacombe, S, Boada, M, Bullock, R, Byrne, J, Camus, V, Cherubini, A, Eriksdotter-Jönhagen, M, Frisoni, GB, Hasselbalch, S, Jones, RW, Martinez-Lage, P, Rikkert, MO, Tsolaki, M, Ousset, PJ, Pasquier, F, Ribera-Casado, JM, Rigaud, AS, Robert, P, Rodriguez, G, Salmon, E, Salva, A, Scheltens, P, Schneider, A, Sinclair, A, Spiru, L, Touchon, J, Zekry, D, Winblad, B & Andrieu, S 2012, 'Progression of Alzheimer disease in Europe: Data from the European ICTUS study', Current Alzheimer Research, vol. 9, no. 8, pp. 902-912. https://doi.org/10.2174/156720512803251066
Vellas, B. ; Hausner, L. ; Frölich, L. ; Cantet, C. ; Gardette, V. ; Reynish, E. ; Gillette, S. ; Agüera-Morales, E. ; Auriacombe, S. ; Boada, M. ; Bullock, R. ; Byrne, J. ; Camus, V. ; Cherubini, A. ; Eriksdotter-Jönhagen, M. ; Frisoni, G. B. ; Hasselbalch, S. ; Jones, R. W. ; Martinez-Lage, P. ; Rikkert, M. O. ; Tsolaki, M. ; Ousset, P. J. ; Pasquier, F. ; Ribera-Casado, J. M. ; Rigaud, A. S. ; Robert, P. ; Rodriguez, G. ; Salmon, E. ; Salva, A. ; Scheltens, P. ; Schneider, A. ; Sinclair, A. ; Spiru, L. ; Touchon, J. ; Zekry, D. ; Winblad, B. ; Andrieu, S. / Progression of Alzheimer disease in Europe : Data from the European ICTUS study. In: Current Alzheimer Research. 2012 ; Vol. 9, No. 8. pp. 902-912.
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AU - Gardette, V.

AU - Reynish, E.

AU - Gillette, S.

AU - Agüera-Morales, E.

AU - Auriacombe, S.

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AU - Byrne, J.

AU - Camus, V.

AU - Cherubini, A.

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AU - Jones, R. W.

AU - Martinez-Lage, P.

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AU - Tsolaki, M.

AU - Ousset, P. J.

AU - Pasquier, F.

AU - Ribera-Casado, J. M.

AU - Rigaud, A. S.

AU - Robert, P.

AU - Rodriguez, G.

AU - Salmon, E.

AU - Salva, A.

AU - Scheltens, P.

AU - Schneider, A.

AU - Sinclair, A.

AU - Spiru, L.

AU - Touchon, J.

AU - Zekry, D.

AU - Winblad, B.

AU - Andrieu, S.

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