Progression of carotid intima-media thickness as predictor of vascular events: Results from the IMPROVE study

Damiano Baldassarre, Fabrizio Veglia, Anders Hamsten, Steve E. Humphries, Rainer Rauramaa, Ulf De Faire, Andries J. Smit, Philippe Giral, Sudhir Kurl, Elmo Mannarino, Enzo Grossi, Rodolfo Paoletti, Elena Tremoli

Research output: Contribution to journalArticlepeer-review


Objective-To investigate whether several different measures of carotid intima-media thickness (IMT) progression are associated with subsequent vascular events and whether such associations are independent of baseline carotid atherosclerotic profile and Framingham risk factors. Approach and Results-A longitudinal cohort study (the Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population study) was performed in 7 centers in 5 European countries (Finland, France, Italy, the Netherlands, and Sweden). Three thousand four hundred eighty-two subjects (median age 64.1 years; 47.8% men) with ≥3 vascular risk factors were recruited and monitored for a postprogression median follow-up of 21.5 months, during which time 129 subjects experienced a first vascular event (incidence of 20.4 per 1000 person-years). The 15th month progression of mean and maximum carotid IMT of the left and right common carotids, bifurcations, internal carotid arteries, and their composite measures, as well as the fastest IMTmax progression (Fastest-IMTmax-progr) detected in the whole carotid tree regardless of location, were used in statistical analyses. All carotid IMT measures showed significant progression during the first 15 months (P

Original languageEnglish
Pages (from-to)2273-2279
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number9
Publication statusPublished - Sep 2013


  • cardiovascular diseases
  • carotid artery intima-media thickness
  • carotid ultrasound
  • progression
  • risk prediction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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