Progression of essential iris atrophy studied with confocal microscopy and ultrasound biomicroscopy

Paola Pivetti Pezzi, Marco Marenco, Pamela Cosimi, Giuseppe Mannino, Ludovico Iannetti

Research output: Contribution to journalArticle

Abstract

PURPOSE: The purpose of this study was to report the progression of the iridocorneal endothelial syndrome during a 5-year period in a patient with the essential iris atrophy variant using confocal microscopy and ultrabiomicroscopy (UBM). METHODS: A 47-year-old woman was referred to us in January 2002 with suspected iridocorneal endothelial syndrome. Examination of both eyes included visual acuity, biomicroscopy, intraocular pressure measurement, gonioscopy, visual field test, and UBM. Afterward, she was examined yearly and confocal microscopy performed. RESULTS: Visual acuity was 20/20 in both eyes. Examination of the right eye revealed endothelial degeneration, peripheral anterior synechiae, and iris atrophy around the pupil that appeared displaced to the temporal side. Biomicroscopy of the left eye was unremarkable. Posterior segment was normal in both eyes. UBM of the right eye showed thickening of the iris adherent to the corneal endothelium. Diagnosis of essential iris atrophy was confirmed. One year later, the right eye showed increasing iridoendothelial adherences confirmed by UBM. Confocal microscopy revealed endothelial cell abnormalities and groups of endothelial "epithelium-like" cells with hyperreflective nuclei. In April 2007, the pupil appeared more temporally dislocated. UBM showed more extended synechiae. Confocal microscopy displayed hyporeflective opacities in the endothelial layer and many grouped keratocytic clusters in the posterior stroma. No alteration of the intraocular pressure and visual field was found during the follow-up. CONCLUSIONS: UBM and confocal microscopy permit observation of any corneal and iridocorneal angle changes and evaluation of essential iris atrophy progression.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalCornea
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2009

Fingerprint

Acoustic Microscopy
Iris
Confocal Microscopy
Atrophy
Iridocorneal Endothelial Syndrome
Pupil
Intraocular Pressure
Visual Acuity
Gonioscopy
Corneal Endothelium
Visual Field Tests
Visual Fields
Epithelium
Endothelial Cells
Observation

Keywords

  • Confocal microscopy
  • Essential iris atrophy
  • Ultrabiomicroscopy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Progression of essential iris atrophy studied with confocal microscopy and ultrasound biomicroscopy. / Pezzi, Paola Pivetti; Marenco, Marco; Cosimi, Pamela; Mannino, Giuseppe; Iannetti, Ludovico.

In: Cornea, Vol. 28, No. 1, 01.2009, p. 99-102.

Research output: Contribution to journalArticle

Pezzi, Paola Pivetti ; Marenco, Marco ; Cosimi, Pamela ; Mannino, Giuseppe ; Iannetti, Ludovico. / Progression of essential iris atrophy studied with confocal microscopy and ultrasound biomicroscopy. In: Cornea. 2009 ; Vol. 28, No. 1. pp. 99-102.
@article{e8d1ff799e4d45a9ba0fafb166ed5a73,
title = "Progression of essential iris atrophy studied with confocal microscopy and ultrasound biomicroscopy",
abstract = "PURPOSE: The purpose of this study was to report the progression of the iridocorneal endothelial syndrome during a 5-year period in a patient with the essential iris atrophy variant using confocal microscopy and ultrabiomicroscopy (UBM). METHODS: A 47-year-old woman was referred to us in January 2002 with suspected iridocorneal endothelial syndrome. Examination of both eyes included visual acuity, biomicroscopy, intraocular pressure measurement, gonioscopy, visual field test, and UBM. Afterward, she was examined yearly and confocal microscopy performed. RESULTS: Visual acuity was 20/20 in both eyes. Examination of the right eye revealed endothelial degeneration, peripheral anterior synechiae, and iris atrophy around the pupil that appeared displaced to the temporal side. Biomicroscopy of the left eye was unremarkable. Posterior segment was normal in both eyes. UBM of the right eye showed thickening of the iris adherent to the corneal endothelium. Diagnosis of essential iris atrophy was confirmed. One year later, the right eye showed increasing iridoendothelial adherences confirmed by UBM. Confocal microscopy revealed endothelial cell abnormalities and groups of endothelial {"}epithelium-like{"} cells with hyperreflective nuclei. In April 2007, the pupil appeared more temporally dislocated. UBM showed more extended synechiae. Confocal microscopy displayed hyporeflective opacities in the endothelial layer and many grouped keratocytic clusters in the posterior stroma. No alteration of the intraocular pressure and visual field was found during the follow-up. CONCLUSIONS: UBM and confocal microscopy permit observation of any corneal and iridocorneal angle changes and evaluation of essential iris atrophy progression.",
keywords = "Confocal microscopy, Essential iris atrophy, Ultrabiomicroscopy",
author = "Pezzi, {Paola Pivetti} and Marco Marenco and Pamela Cosimi and Giuseppe Mannino and Ludovico Iannetti",
year = "2009",
month = "1",
doi = "10.1097/ICO.0b013e3181822579",
language = "English",
volume = "28",
pages = "99--102",
journal = "Cornea",
issn = "0277-3740",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Progression of essential iris atrophy studied with confocal microscopy and ultrasound biomicroscopy

AU - Pezzi, Paola Pivetti

AU - Marenco, Marco

AU - Cosimi, Pamela

AU - Mannino, Giuseppe

AU - Iannetti, Ludovico

PY - 2009/1

Y1 - 2009/1

N2 - PURPOSE: The purpose of this study was to report the progression of the iridocorneal endothelial syndrome during a 5-year period in a patient with the essential iris atrophy variant using confocal microscopy and ultrabiomicroscopy (UBM). METHODS: A 47-year-old woman was referred to us in January 2002 with suspected iridocorneal endothelial syndrome. Examination of both eyes included visual acuity, biomicroscopy, intraocular pressure measurement, gonioscopy, visual field test, and UBM. Afterward, she was examined yearly and confocal microscopy performed. RESULTS: Visual acuity was 20/20 in both eyes. Examination of the right eye revealed endothelial degeneration, peripheral anterior synechiae, and iris atrophy around the pupil that appeared displaced to the temporal side. Biomicroscopy of the left eye was unremarkable. Posterior segment was normal in both eyes. UBM of the right eye showed thickening of the iris adherent to the corneal endothelium. Diagnosis of essential iris atrophy was confirmed. One year later, the right eye showed increasing iridoendothelial adherences confirmed by UBM. Confocal microscopy revealed endothelial cell abnormalities and groups of endothelial "epithelium-like" cells with hyperreflective nuclei. In April 2007, the pupil appeared more temporally dislocated. UBM showed more extended synechiae. Confocal microscopy displayed hyporeflective opacities in the endothelial layer and many grouped keratocytic clusters in the posterior stroma. No alteration of the intraocular pressure and visual field was found during the follow-up. CONCLUSIONS: UBM and confocal microscopy permit observation of any corneal and iridocorneal angle changes and evaluation of essential iris atrophy progression.

AB - PURPOSE: The purpose of this study was to report the progression of the iridocorneal endothelial syndrome during a 5-year period in a patient with the essential iris atrophy variant using confocal microscopy and ultrabiomicroscopy (UBM). METHODS: A 47-year-old woman was referred to us in January 2002 with suspected iridocorneal endothelial syndrome. Examination of both eyes included visual acuity, biomicroscopy, intraocular pressure measurement, gonioscopy, visual field test, and UBM. Afterward, she was examined yearly and confocal microscopy performed. RESULTS: Visual acuity was 20/20 in both eyes. Examination of the right eye revealed endothelial degeneration, peripheral anterior synechiae, and iris atrophy around the pupil that appeared displaced to the temporal side. Biomicroscopy of the left eye was unremarkable. Posterior segment was normal in both eyes. UBM of the right eye showed thickening of the iris adherent to the corneal endothelium. Diagnosis of essential iris atrophy was confirmed. One year later, the right eye showed increasing iridoendothelial adherences confirmed by UBM. Confocal microscopy revealed endothelial cell abnormalities and groups of endothelial "epithelium-like" cells with hyperreflective nuclei. In April 2007, the pupil appeared more temporally dislocated. UBM showed more extended synechiae. Confocal microscopy displayed hyporeflective opacities in the endothelial layer and many grouped keratocytic clusters in the posterior stroma. No alteration of the intraocular pressure and visual field was found during the follow-up. CONCLUSIONS: UBM and confocal microscopy permit observation of any corneal and iridocorneal angle changes and evaluation of essential iris atrophy progression.

KW - Confocal microscopy

KW - Essential iris atrophy

KW - Ultrabiomicroscopy

UR - http://www.scopus.com/inward/record.url?scp=62149125234&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62149125234&partnerID=8YFLogxK

U2 - 10.1097/ICO.0b013e3181822579

DO - 10.1097/ICO.0b013e3181822579

M3 - Article

C2 - 19092417

AN - SCOPUS:62149125234

VL - 28

SP - 99

EP - 102

JO - Cornea

JF - Cornea

SN - 0277-3740

IS - 1

ER -