Abstract
We performed a longitudinal study (mean follow-up 86.7 months) to evaluate motor and mental deterioration in patients with Parkinson's disease. Of the original 91 patients, only 61 could be re-examined 7 years later and 11 of these had become demented (PD-Dems). PD-Dems were older with worse motor and, obviously, cognitive performance than non-demented parkinsonian patients (PDs). A global cognitive decay index (DI) was calculated for each patient. Based on this, non-demented PDs were further split into 38 stable parkinsonian patients (S-PDs) with DI -30% to +30%, and 10 deteriorated but non-demented parkinsonian patients (D-PDs) with a DI worse than -30% (as had PD-Dems). D-PDs were older and had greater motor impairment than S-PDs but did not differ from PD-Dems on these measures. D-PDs and PD-Dems deteriorated especially in attention, visuospatial and executive ability tests. Ageing seems to be the main predictive factor for mental deterioration.
| Original language | English |
|---|---|
| Pages (from-to) | 535-540 |
| Number of pages | 6 |
| Journal | Journal of Neurology |
| Volume | 242 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1995 |
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Keywords
- Mental deterioration
- Parkinson's disease Dementia
- Stable parkinsonism
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Progression of motor and cognitive impairment in Parkinson's disease. / Palazzini, E.; Soliveri, P.; Filippini, G.; Fetoni, V.; Zappacosta, B.; Scigliano, G.; Monza, D.; Caraceni, T.; Girotti, F.
In: Journal of Neurology, Vol. 242, No. 8, 08.1995, p. 535-540.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Progression of motor and cognitive impairment in Parkinson's disease
AU - Palazzini, E.
AU - Soliveri, P.
AU - Filippini, G.
AU - Fetoni, V.
AU - Zappacosta, B.
AU - Scigliano, G.
AU - Monza, D.
AU - Caraceni, T.
AU - Girotti, F.
PY - 1995/8
Y1 - 1995/8
N2 - We performed a longitudinal study (mean follow-up 86.7 months) to evaluate motor and mental deterioration in patients with Parkinson's disease. Of the original 91 patients, only 61 could be re-examined 7 years later and 11 of these had become demented (PD-Dems). PD-Dems were older with worse motor and, obviously, cognitive performance than non-demented parkinsonian patients (PDs). A global cognitive decay index (DI) was calculated for each patient. Based on this, non-demented PDs were further split into 38 stable parkinsonian patients (S-PDs) with DI -30% to +30%, and 10 deteriorated but non-demented parkinsonian patients (D-PDs) with a DI worse than -30% (as had PD-Dems). D-PDs were older and had greater motor impairment than S-PDs but did not differ from PD-Dems on these measures. D-PDs and PD-Dems deteriorated especially in attention, visuospatial and executive ability tests. Ageing seems to be the main predictive factor for mental deterioration.
AB - We performed a longitudinal study (mean follow-up 86.7 months) to evaluate motor and mental deterioration in patients with Parkinson's disease. Of the original 91 patients, only 61 could be re-examined 7 years later and 11 of these had become demented (PD-Dems). PD-Dems were older with worse motor and, obviously, cognitive performance than non-demented parkinsonian patients (PDs). A global cognitive decay index (DI) was calculated for each patient. Based on this, non-demented PDs were further split into 38 stable parkinsonian patients (S-PDs) with DI -30% to +30%, and 10 deteriorated but non-demented parkinsonian patients (D-PDs) with a DI worse than -30% (as had PD-Dems). D-PDs were older and had greater motor impairment than S-PDs but did not differ from PD-Dems on these measures. D-PDs and PD-Dems deteriorated especially in attention, visuospatial and executive ability tests. Ageing seems to be the main predictive factor for mental deterioration.
KW - Mental deterioration
KW - Parkinson's disease Dementia
KW - Stable parkinsonism
UR - http://www.scopus.com/inward/record.url?scp=0029078632&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029078632&partnerID=8YFLogxK
U2 - 10.1007/BF00867426
DO - 10.1007/BF00867426
M3 - Article
C2 - 8530983
AN - SCOPUS:0029078632
VL - 242
SP - 535
EP - 540
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 8
ER -