Progression of motor and cognitive impairment in Parkinson's disease

E. Palazzini, P. Soliveri, G. Filippini, V. Fetoni, B. Zappacosta, G. Scigliano, D. Monza, T. Caraceni, F. Girotti

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Abstract

We performed a longitudinal study (mean follow-up 86.7 months) to evaluate motor and mental deterioration in patients with Parkinson's disease. Of the original 91 patients, only 61 could be re-examined 7 years later and 11 of these had become demented (PD-Dems). PD-Dems were older with worse motor and, obviously, cognitive performance than non-demented parkinsonian patients (PDs). A global cognitive decay index (DI) was calculated for each patient. Based on this, non-demented PDs were further split into 38 stable parkinsonian patients (S-PDs) with DI -30% to +30%, and 10 deteriorated but non-demented parkinsonian patients (D-PDs) with a DI worse than -30% (as had PD-Dems). D-PDs were older and had greater motor impairment than S-PDs but did not differ from PD-Dems on these measures. D-PDs and PD-Dems deteriorated especially in attention, visuospatial and executive ability tests. Ageing seems to be the main predictive factor for mental deterioration.

Original languageEnglish
Pages (from-to)535-540
Number of pages6
JournalJournal of Neurology
Volume242
Issue number8
DOIs
Publication statusPublished - Aug 1995

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Parkinson Disease
Aptitude
Longitudinal Studies
Cognitive Dysfunction

Keywords

  • Mental deterioration
  • Parkinson's disease Dementia
  • Stable parkinsonism

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Palazzini, E., Soliveri, P., Filippini, G., Fetoni, V., Zappacosta, B., Scigliano, G., ... Girotti, F. (1995). Progression of motor and cognitive impairment in Parkinson's disease. Journal of Neurology, 242(8), 535-540. https://doi.org/10.1007/BF00867426

Progression of motor and cognitive impairment in Parkinson's disease. / Palazzini, E.; Soliveri, P.; Filippini, G.; Fetoni, V.; Zappacosta, B.; Scigliano, G.; Monza, D.; Caraceni, T.; Girotti, F.

In: Journal of Neurology, Vol. 242, No. 8, 08.1995, p. 535-540.

Research output: Contribution to journalArticle

Palazzini, E, Soliveri, P, Filippini, G, Fetoni, V, Zappacosta, B, Scigliano, G, Monza, D, Caraceni, T & Girotti, F 1995, 'Progression of motor and cognitive impairment in Parkinson's disease', Journal of Neurology, vol. 242, no. 8, pp. 535-540. https://doi.org/10.1007/BF00867426
Palazzini E, Soliveri P, Filippini G, Fetoni V, Zappacosta B, Scigliano G et al. Progression of motor and cognitive impairment in Parkinson's disease. Journal of Neurology. 1995 Aug;242(8):535-540. https://doi.org/10.1007/BF00867426
Palazzini, E. ; Soliveri, P. ; Filippini, G. ; Fetoni, V. ; Zappacosta, B. ; Scigliano, G. ; Monza, D. ; Caraceni, T. ; Girotti, F. / Progression of motor and cognitive impairment in Parkinson's disease. In: Journal of Neurology. 1995 ; Vol. 242, No. 8. pp. 535-540.
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