Progression of MRI abnormalities in herpes simplex encephalitis despite clinical improvement

Natural history or disease progression?

Paola Gaviani, M. Leone, M. Mula, P. Naldi, E. Macchiarulo, D. Brustia, F. Monaco

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Herpes simplex virus encephalitis (HSVE) is associated with a high mortality rate and a high probability of neurological sequelae. Good results are obtained when HSVE is promptly diagnosed and treated with acyclovir. We present a 71-year-old woman with clinically diagnosed HSVE, confirmed by PCR detection of HSV-1 DNA in the cerebrospinal fluid. She was treated with acyclovir (30mg/kg day) for two weeks. Clinical and neuropsychological assessments 6 months after admission were normal; however MRI at 2, 6 and 12 months showed progressive deterioration with extensive white matter and cortical damage. Imaging studies of a cohort of patients surviving PCR-confirmed HSVE are needed to determine whether this pattern is occasional or a frequent form of progression.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalNeurological Sciences
Volume25
Issue number2
Publication statusPublished - Jun 2004

Fingerprint

Herpes Simplex Encephalitis
Simplexvirus
Natural History
Disease Progression
Acyclovir
Polymerase Chain Reaction
Human Herpesvirus 1
Cerebrospinal Fluid
Cohort Studies
Mortality
DNA

Keywords

  • Herpes simplex encephalitis
  • MRI
  • Neuropsychological assessment
  • Prognosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Progression of MRI abnormalities in herpes simplex encephalitis despite clinical improvement : Natural history or disease progression? / Gaviani, Paola; Leone, M.; Mula, M.; Naldi, P.; Macchiarulo, E.; Brustia, D.; Monaco, F.

In: Neurological Sciences, Vol. 25, No. 2, 06.2004, p. 104-107.

Research output: Contribution to journalArticle

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