Progression of MRI abnormalities in herpes simplex encephalitis despite clinical improvement: Natural history or disease progression?

Paola Gaviani, M. Leone, M. Mula, P. Naldi, E. Macchiarulo, D. Brustia, F. Monaco

Research output: Contribution to journalArticle

Abstract

Herpes simplex virus encephalitis (HSVE) is associated with a high mortality rate and a high probability of neurological sequelae. Good results are obtained when HSVE is promptly diagnosed and treated with acyclovir. We present a 71-year-old woman with clinically diagnosed HSVE, confirmed by PCR detection of HSV-1 DNA in the cerebrospinal fluid. She was treated with acyclovir (30mg/kg day) for two weeks. Clinical and neuropsychological assessments 6 months after admission were normal; however MRI at 2, 6 and 12 months showed progressive deterioration with extensive white matter and cortical damage. Imaging studies of a cohort of patients surviving PCR-confirmed HSVE are needed to determine whether this pattern is occasional or a frequent form of progression.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalNeurological Sciences
Volume25
Issue number2
Publication statusPublished - Jun 2004

Fingerprint

Herpes Simplex Encephalitis
Simplexvirus
Natural History
Disease Progression
Acyclovir
Polymerase Chain Reaction
Human Herpesvirus 1
Cerebrospinal Fluid
Cohort Studies
Mortality
DNA

Keywords

  • Herpes simplex encephalitis
  • MRI
  • Neuropsychological assessment
  • Prognosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Progression of MRI abnormalities in herpes simplex encephalitis despite clinical improvement : Natural history or disease progression? / Gaviani, Paola; Leone, M.; Mula, M.; Naldi, P.; Macchiarulo, E.; Brustia, D.; Monaco, F.

In: Neurological Sciences, Vol. 25, No. 2, 06.2004, p. 104-107.

Research output: Contribution to journalArticle

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