Progression of renal damage in chronic rejection

Claudio Ponticelli

Research output: Contribution to journalArticle

Abstract

A significant complication in renal transplantation is the progressive decline of allograft function, commonly called chronic rejection. This complication has been regarded as a result of continuous immunological activity against the allograft. However, the role of nonimmunological factors has become increasingly apparent in triggering or exacerbating immunological mechanisms. Although the role of immunological factors is predominant, the correction of nonimmunological factors may contribute in improving the probability of long-term graft function. However, immunosuppressive therapy remains the cornerstone for reducing the risk of chronic rejection and late graft failure.

Original languageEnglish
JournalKidney international. Supplement
Volume57
Issue number75
Publication statusPublished - 2000

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Keywords

  • Allograft function
  • Nephropathy
  • Pathogenesis
  • Rejection
  • Transplantation

ASJC Scopus subject areas

  • Nephrology

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