Progression of renal damage in glycogen storage disease type i is associated to hyperlipidemia: A multicenter prospective Italian study

Daniela Melis, Mariarosaria Cozzolino, Giorgia Minopoli, Francesca Balivo, Rossella Parini, Miriam Rigoldi, Sabrina Paci, Carlo Dionisi-Vici, Alberto Burlina, Generoso Andria, Giancarlo Parenti

Research output: Contribution to journalArticlepeer-review

Abstract

Angiotensin converting enzyme (ACE)-inhibitors decrease glomerular hyperfiltration but not microalbuminuria and proteinuria in glycogen storage disease type I. In the current study, we demonstrated that severe hyperlipidemia is associated with ACE-inhibitor ineffectiveness. We underline the importance of adequate metabolic control in glycogen storage disease type I. A combination therapy with ACE-inhibitors and lipid lowering drugs might be considered.

Original languageEnglish
Pages (from-to)1079-1082
Number of pages4
JournalJournal of Pediatrics
Volume166
Issue number4
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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