Progression of striatal and extrastriatal degeneration in multiple system atrophy

A longitudinal diffusion-weighted MR study

Maria Teresa Pellecchia, Paolo Barone, Caterina Vicidomini, Carmine Mollica, Elena Salvatore, Marta Ianniciello, Raffaele Liuzzi, Katia Longo, Marina Picillo, Giuseppe De Michele, Alessandro Filla, Arturo Brunetti, Marco Salvatore, Sabina Pappatà

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Diffusion-weighted imaging has been largely used to detect and quantify early degenerative changes in patients with multiple system atrophy, but progression of neurodegeneration has been poorly investigated. We performed a serial diffusion-weighted imaging study in a population of multiple system atrophy patients and analyzed the evolution of diffusion properties in striatal and extrastriatal brain regions. Diffusion-weighted imaging was obtained in 11 multiple system atrophy patients at baseline and after a follow-up of 11.7 ± 1.2 months, and Trace (D) changes in different brain regions were correlated with disease duration and severity. A significant increase in Trace (D) was observed at follow-up in the putamen (P <.001), pons (P = .003), cerebellar white matter (P = .03), thalamus (P = .013), and frontal white matter (P = .021). Both Unified Multiple System Atrophy Rating Scale Part II and Unified Parkinson's Disease Rating Scale Part III scores significantly increased at follow-up (P = .003), but percent changes of Unified Parkinson's Disease Rating Scale Part III and Unified Multiple System Atrophy Rating Scale Part II did not correlate with percent changes of Trace (D) values in any brain region. This longitudinal study provides new insights into the progression of neurodegeneration in different brain regions in multiple system atrophy. Our results confirm that abnormal diffusivity in the putamen is sensitive to change over time in multiple system atrophy patients and show for the first time a progression of Trace (D) alterations in specific extrastriatal regions. Diffusivity changes in these regions may be useful for monitoring disease progression even after a short follow-up period.

Original languageEnglish
Pages (from-to)1303-1309
Number of pages7
JournalMovement Disorders
Volume26
Issue number7
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Multiple System Atrophy
Corpus Striatum
Putamen
Brain
Parkinson Disease
Pons
Thalamus
Longitudinal Studies
Disease Progression

Keywords

  • Diffusion-weighted imaging
  • Longitudinal study
  • Multiple system atrophy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Pellecchia, M. T., Barone, P., Vicidomini, C., Mollica, C., Salvatore, E., Ianniciello, M., ... Pappatà, S. (2011). Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion-weighted MR study. Movement Disorders, 26(7), 1303-1309. https://doi.org/10.1002/mds.23601

Progression of striatal and extrastriatal degeneration in multiple system atrophy : A longitudinal diffusion-weighted MR study. / Pellecchia, Maria Teresa; Barone, Paolo; Vicidomini, Caterina; Mollica, Carmine; Salvatore, Elena; Ianniciello, Marta; Liuzzi, Raffaele; Longo, Katia; Picillo, Marina; De Michele, Giuseppe; Filla, Alessandro; Brunetti, Arturo; Salvatore, Marco; Pappatà, Sabina.

In: Movement Disorders, Vol. 26, No. 7, 06.2011, p. 1303-1309.

Research output: Contribution to journalArticle

Pellecchia, MT, Barone, P, Vicidomini, C, Mollica, C, Salvatore, E, Ianniciello, M, Liuzzi, R, Longo, K, Picillo, M, De Michele, G, Filla, A, Brunetti, A, Salvatore, M & Pappatà, S 2011, 'Progression of striatal and extrastriatal degeneration in multiple system atrophy: A longitudinal diffusion-weighted MR study', Movement Disorders, vol. 26, no. 7, pp. 1303-1309. https://doi.org/10.1002/mds.23601
Pellecchia, Maria Teresa ; Barone, Paolo ; Vicidomini, Caterina ; Mollica, Carmine ; Salvatore, Elena ; Ianniciello, Marta ; Liuzzi, Raffaele ; Longo, Katia ; Picillo, Marina ; De Michele, Giuseppe ; Filla, Alessandro ; Brunetti, Arturo ; Salvatore, Marco ; Pappatà, Sabina. / Progression of striatal and extrastriatal degeneration in multiple system atrophy : A longitudinal diffusion-weighted MR study. In: Movement Disorders. 2011 ; Vol. 26, No. 7. pp. 1303-1309.
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