Progression of tumefactive demyelinating lesion in a child demonstrated with MRI

Marta De Simone, Barbara Brogna, Daniele Litterio Spitaleri, Giulio Cicarelli, Roberta Fantozzi, Bruno Guida

Research output: Contribution to journalArticlepeer-review


Tumefactive demyelinating lesions (TDLs) are atypical presentations of various demyelinating diseases. They can mimic brain tumors in their clinical and radiological features and usually respond favorably to corticosteroid therapy. We report a case of a 17-year-old girl with a single TDL suddenly increasing in size even under steroid therapy. She underwent very strict follow-up examinations with conventional magnetic resonance and diffusion-weighted imaging, perfusion-weighted imaging, proton-magnetic resonance spectroscopy. The behavior of the lesion during the different follow-up sessions posed a diagnostic challenge as it expanded its size during the final examination, in stark contrast to what we forecast. Diagnosis of TDL was initially hypothesized, but the aggressive behavior of the lesion required biopsy.

Original languageEnglish
Pages (from-to)254-260
Number of pages7
JournalRadiology Case Reports
Issue number1
Publication statusPublished - Feb 1 2018


  • Brain tumor
  • MR diffusion
  • MR imaging perfusion
  • MR imaging spectroscopy
  • Tumefactive demyelinating lesion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Progression of tumefactive demyelinating lesion in a child demonstrated with MRI'. Together they form a unique fingerprint.

Cite this