TY - JOUR
T1 - Progression of white matter damage in progressive supranuclear palsy with predominant parkinsonism
AU - Caso, F
AU - Agosta, F
AU - Ječmenica-Lukić, M
AU - Petrović, I
AU - Meani, Alessandro
AU - Kostic, VS
AU - Filippi, M
PY - 2018
Y1 - 2018
N2 - Introduction: Progressive supranuclear palsy with predominant parkinsonism (PSP-P) accounts for 14–35% of all PSP cases. A few cross-sectional MRI studies in PSP-P showed a remarkable white matter (WM) damage. Progression of brain structural damage in these patients remains unknown. Methods: Longitudinal clinical, cognitive and diffusion tensor (DT) MRI data were obtained over a mean 1.6 year follow up in 10 PSP-P patients. At study entry, patients were compared with 36 healthy controls. Voxelwise statistical analysis of white matter DT MRI data (mean, axial and radial diffusivity, and fractional anisotropy) was carried out using tract-based spatial statistics. Results: During the 1.6 year follow up, PSP-P patients showed significant decline of motor, cognitive and mood disturbances. DT MRI analysis revealed at baseline a widespread pattern of WM alterations. Over time, PSP-P patients exhibited progression of WM damage in supratentorial tracts compared to baseline. No WM changes were detected in cerebellar WM. Conclusions: In PSP-P patients, WM damage significantly progressed over time. Longitudinal DT MRI measures are a potential in vivo marker of disease progression in PSP-P. © 2018 Elsevier Ltd
AB - Introduction: Progressive supranuclear palsy with predominant parkinsonism (PSP-P) accounts for 14–35% of all PSP cases. A few cross-sectional MRI studies in PSP-P showed a remarkable white matter (WM) damage. Progression of brain structural damage in these patients remains unknown. Methods: Longitudinal clinical, cognitive and diffusion tensor (DT) MRI data were obtained over a mean 1.6 year follow up in 10 PSP-P patients. At study entry, patients were compared with 36 healthy controls. Voxelwise statistical analysis of white matter DT MRI data (mean, axial and radial diffusivity, and fractional anisotropy) was carried out using tract-based spatial statistics. Results: During the 1.6 year follow up, PSP-P patients showed significant decline of motor, cognitive and mood disturbances. DT MRI analysis revealed at baseline a widespread pattern of WM alterations. Over time, PSP-P patients exhibited progression of WM damage in supratentorial tracts compared to baseline. No WM changes were detected in cerebellar WM. Conclusions: In PSP-P patients, WM damage significantly progressed over time. Longitudinal DT MRI measures are a potential in vivo marker of disease progression in PSP-P. © 2018 Elsevier Ltd
U2 - 10.1016/j.parkreldis.2018.01.001
DO - 10.1016/j.parkreldis.2018.01.001
M3 - Article
VL - 49
SP - 95
EP - 99
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
SN - 1353-8020
IS - 2
ER -