Progression to AIDS among Italian HIV-seropositive haemophiliacs

Nicola Schinaia, Alessandro Ghirardini, Flavia Chiarotti, Alessandro Gringeri, Pier M. Mannucci

Research output: Contribution to journalArticlepeer-review


To investigate the interval between HIV-1 infection and the development of clinical AIDS among Italian patients with congenital coagulation disorders, a national cohort study was undertaken in 1988. Information was collected both retrospectively and prospectively on 499 HIV-1-positive patients enrolled in an ongoing national registry of patients with congenital coagulation disorders. Two methods were used to estimate each patient's seroconversion date: the mid-point between the last negative (either known or estimated) and the first positive test, and the median under a Weibull distribution, which was assumed to fit seroconversion data. The two methods of estimating the seroconversion time yielded similar results. The actuarial incidence of AIDS was estimated using the Kaplan-Meier survival analysis at 12.8% (95% confidence interval = 9.7-15.9) over 7 years for Italian haemophiliacs. Progression appears to be slow in the first 5 years after the infection, and to rise steadily thereafter. A strong association between faster progression and older age at seroconversion was found. Zidovudine-treated individuals seem to have a slower progression than untreated individuals, after controlling for CD4, but there was no association between progression and type and severity of the congenital disorder.

Original languageEnglish
Pages (from-to)385-391
Number of pages7
JournalAIDS (London, England)
Issue number4
Publication statusPublished - Apr 1991


  • Factor IX concentrates
  • Factor VIII concentrates
  • Haemophilia
  • HIV-1 infection
  • Italy
  • Survival analysis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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