Progressive and persistent downregulation of surface CXCR4 in CD4+ T cells infected with human herpesvirus 7

Paola Secchiero, Davide Zella, Oxana Barabitskaja, Marvin S. Reitz, Silvano Capitani, Robert C. Gallo, Giorgio Zauli

Research output: Contribution to journalArticle

Abstract

We have previously shown that infection of CD4+ T lymphocytes with the T-lymphotropic human herpesvirus 7 (HHV-7) downregulates surface CD4, which represents the high-affinity receptor for HHV-7. In this study, we report that HHV-7 infection also causes a progressive loss of the surface CXC- chemokine receptor 4 (CXCR4) in CD4+ T cells, accompanied by a reduced intracellular Ca2+ flux and chemotaxis in response to stromal cell-derived factor-1α (SDF-1α), the specific CXCR4 ligand. Moreover, CXCR4 is downregulated from the surface of HHV-7-infected T cells independently of CD4. Because intracellular CXCR4 antigen and mRNA levels are unaffected in productively HHV-7-infected cells, the downregulation of CXCR4 apparently does not involve a transcritional block. Since CXCR4 functions in association with CD4 to permit entry of several human immunodeficiency virus (HIV) isolates, the potential of HHV-7 to persistently downregulate the surface expression of CXCR4 may provide novel strategies for limiting HIV infection.

Original languageEnglish
Pages (from-to)4521-4528
Number of pages8
JournalBlood
Volume92
Issue number12
Publication statusPublished - Dec 15 1998

ASJC Scopus subject areas

  • Hematology

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    Secchiero, P., Zella, D., Barabitskaja, O., Reitz, M. S., Capitani, S., Gallo, R. C., & Zauli, G. (1998). Progressive and persistent downregulation of surface CXCR4 in CD4+ T cells infected with human herpesvirus 7. Blood, 92(12), 4521-4528.