Progressive disruption of the circadian rhythm of melatonin in fatal familial insomnia

Francesco Portaluppi, Pietro Cortelli, Patrizia Avoni, Luciana Vergnani, Paolo Maltoni, Anna Pavani, Emilia Sforza, Ettore C. Degli Uberti, Pierluigi Gambetti, Elio Lugaresi

Research output: Contribution to journalArticle

Abstract

Fatal familial insomnia (FFI) is a disease characterized by loss of sleep activity due to selective thalamic degeneration. To assess the secretory pattern of melatonin (MT) in FFI, we studied two cases of overt disease under standardized conditions and polysomnographic control. Each patient underwent repeated 24-h study sessions, and MT was assayed at 30-min intervals. Six healthy volunteers were used as controls. Slow wave sleep was never recorded, whereas occasional episodes of enacted dreaming accompanied by rapid ocular movements and complex muscular activities were documented, with no detectable rhythm. Plasma MT concentrations gradually decreased as the disease progressed. A significant circadian rhythm was detected in the earlier recordings, with decreasing amplitudes with disease progression. Complete rhythm obliteration was achieved in the most advanced stage. Normally placed nocturnal acrophases were detected in the earlier stages, but then a shift toward the daytime hours was observed. Thalamic lesions of FFI appear to determine a progressive disruption of the sleep/wake cycle accompanied by decreased circulating levels of MT, with progressive alterations in the circadian rhythm of this hormone. On the other hand, decreased secretion of MT may contribute to the sleep disturbances of FFI.

Original languageEnglish
Pages (from-to)1075-1078
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume78
Issue number5
DOIs
Publication statusPublished - May 1994

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Fatal Familial Insomnia
Melatonin
Circadian Rhythm
Sleep
REM Sleep
Disease Progression
Healthy Volunteers
Hormones
Plasmas

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Progressive disruption of the circadian rhythm of melatonin in fatal familial insomnia. / Portaluppi, Francesco; Cortelli, Pietro; Avoni, Patrizia; Vergnani, Luciana; Maltoni, Paolo; Pavani, Anna; Sforza, Emilia; Degli Uberti, Ettore C.; Gambetti, Pierluigi; Lugaresi, Elio.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 78, No. 5, 05.1994, p. 1075-1078.

Research output: Contribution to journalArticle

Portaluppi, F, Cortelli, P, Avoni, P, Vergnani, L, Maltoni, P, Pavani, A, Sforza, E, Degli Uberti, EC, Gambetti, P & Lugaresi, E 1994, 'Progressive disruption of the circadian rhythm of melatonin in fatal familial insomnia', Journal of Clinical Endocrinology and Metabolism, vol. 78, no. 5, pp. 1075-1078. https://doi.org/10.1210/jc.78.5.1075
Portaluppi, Francesco ; Cortelli, Pietro ; Avoni, Patrizia ; Vergnani, Luciana ; Maltoni, Paolo ; Pavani, Anna ; Sforza, Emilia ; Degli Uberti, Ettore C. ; Gambetti, Pierluigi ; Lugaresi, Elio. / Progressive disruption of the circadian rhythm of melatonin in fatal familial insomnia. In: Journal of Clinical Endocrinology and Metabolism. 1994 ; Vol. 78, No. 5. pp. 1075-1078.
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