Progressive hepatic fibrosis in healthy carriers of hepatitis C virus with a transaminase breakthrough

Maria Grazia Rumi, F. De Filippi, M. F. Donato, E. Del Ninno, M. Colombo

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

In short-term studies, patients with chronic hepatitis C virus (HCV) infection, consistently normal serum aminotransferase (ALT) levels, and minimal or mild necro-inflammatory changes in the liver, did not progress to histologically severe hepatitis. There are no data on longer term outcome of liver disease in these patients. We describe two patients with HCV infection (genotype 2c) with a rise in serum ALT values greater than 10 times the upper normal value that occurred after an 8- and 15-year period of persistently normal or minimally elevated ALT levels. In both patients, the rise in ALT values lasted more than 16 weeks and was not associated with any symptom or risk factor for acute hepatitis. A liver biopsy performed 4 and 18 months after the ALT flare showed clear-cut progression from chronic hepatitis with mild activity to chronic hepatitis with severe activity and central to portal septal fibrosis (Ishak score: grading 14 and 6; staging: 4 and 5, respectively). Hence, extended surveillance of HCV carriers with consistently normal or minimally elevated ALT values is warranted as these patients are at risk of ALT flares and may develop progressive liver disease.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalJournal of Viral Hepatitis
Volume9
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

Transaminases
Hepacivirus
Fibrosis
Liver
Virus Diseases
Chronic Hepatitis
Hepatitis
Liver Diseases
Chronic Hepatitis C
Serum
Reference Values
Genotype
Biopsy

Keywords

  • Alanine aminotransferase flares
  • Asymptomatic carriers
  • Fibrosis
  • Genotype 2c
  • Hepatitis C virus

ASJC Scopus subject areas

  • Hepatology
  • Virology

Cite this

Progressive hepatic fibrosis in healthy carriers of hepatitis C virus with a transaminase breakthrough. / Rumi, Maria Grazia; De Filippi, F.; Donato, M. F.; Del Ninno, E.; Colombo, M.

In: Journal of Viral Hepatitis, Vol. 9, No. 1, 2002, p. 71-74.

Research output: Contribution to journalArticle

@article{d07b5d9180434c8a83f62bdb4a0ff523,
title = "Progressive hepatic fibrosis in healthy carriers of hepatitis C virus with a transaminase breakthrough",
abstract = "In short-term studies, patients with chronic hepatitis C virus (HCV) infection, consistently normal serum aminotransferase (ALT) levels, and minimal or mild necro-inflammatory changes in the liver, did not progress to histologically severe hepatitis. There are no data on longer term outcome of liver disease in these patients. We describe two patients with HCV infection (genotype 2c) with a rise in serum ALT values greater than 10 times the upper normal value that occurred after an 8- and 15-year period of persistently normal or minimally elevated ALT levels. In both patients, the rise in ALT values lasted more than 16 weeks and was not associated with any symptom or risk factor for acute hepatitis. A liver biopsy performed 4 and 18 months after the ALT flare showed clear-cut progression from chronic hepatitis with mild activity to chronic hepatitis with severe activity and central to portal septal fibrosis (Ishak score: grading 14 and 6; staging: 4 and 5, respectively). Hence, extended surveillance of HCV carriers with consistently normal or minimally elevated ALT values is warranted as these patients are at risk of ALT flares and may develop progressive liver disease.",
keywords = "Alanine aminotransferase flares, Asymptomatic carriers, Fibrosis, Genotype 2c, Hepatitis C virus",
author = "Rumi, {Maria Grazia} and {De Filippi}, F. and Donato, {M. F.} and {Del Ninno}, E. and M. Colombo",
year = "2002",
doi = "10.1046/j.1365-2893.2002.00328.x",
language = "English",
volume = "9",
pages = "71--74",
journal = "Journal of Viral Hepatitis",
issn = "1352-0504",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "1",

}

TY - JOUR

T1 - Progressive hepatic fibrosis in healthy carriers of hepatitis C virus with a transaminase breakthrough

AU - Rumi, Maria Grazia

AU - De Filippi, F.

AU - Donato, M. F.

AU - Del Ninno, E.

AU - Colombo, M.

PY - 2002

Y1 - 2002

N2 - In short-term studies, patients with chronic hepatitis C virus (HCV) infection, consistently normal serum aminotransferase (ALT) levels, and minimal or mild necro-inflammatory changes in the liver, did not progress to histologically severe hepatitis. There are no data on longer term outcome of liver disease in these patients. We describe two patients with HCV infection (genotype 2c) with a rise in serum ALT values greater than 10 times the upper normal value that occurred after an 8- and 15-year period of persistently normal or minimally elevated ALT levels. In both patients, the rise in ALT values lasted more than 16 weeks and was not associated with any symptom or risk factor for acute hepatitis. A liver biopsy performed 4 and 18 months after the ALT flare showed clear-cut progression from chronic hepatitis with mild activity to chronic hepatitis with severe activity and central to portal septal fibrosis (Ishak score: grading 14 and 6; staging: 4 and 5, respectively). Hence, extended surveillance of HCV carriers with consistently normal or minimally elevated ALT values is warranted as these patients are at risk of ALT flares and may develop progressive liver disease.

AB - In short-term studies, patients with chronic hepatitis C virus (HCV) infection, consistently normal serum aminotransferase (ALT) levels, and minimal or mild necro-inflammatory changes in the liver, did not progress to histologically severe hepatitis. There are no data on longer term outcome of liver disease in these patients. We describe two patients with HCV infection (genotype 2c) with a rise in serum ALT values greater than 10 times the upper normal value that occurred after an 8- and 15-year period of persistently normal or minimally elevated ALT levels. In both patients, the rise in ALT values lasted more than 16 weeks and was not associated with any symptom or risk factor for acute hepatitis. A liver biopsy performed 4 and 18 months after the ALT flare showed clear-cut progression from chronic hepatitis with mild activity to chronic hepatitis with severe activity and central to portal septal fibrosis (Ishak score: grading 14 and 6; staging: 4 and 5, respectively). Hence, extended surveillance of HCV carriers with consistently normal or minimally elevated ALT values is warranted as these patients are at risk of ALT flares and may develop progressive liver disease.

KW - Alanine aminotransferase flares

KW - Asymptomatic carriers

KW - Fibrosis

KW - Genotype 2c

KW - Hepatitis C virus

UR - http://www.scopus.com/inward/record.url?scp=0036905695&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036905695&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2893.2002.00328.x

DO - 10.1046/j.1365-2893.2002.00328.x

M3 - Article

C2 - 11851905

AN - SCOPUS:0036905695

VL - 9

SP - 71

EP - 74

JO - Journal of Viral Hepatitis

JF - Journal of Viral Hepatitis

SN - 1352-0504

IS - 1

ER -