Progressive histiocytosis: Description of a case of slow-course non-langerhans cell histiocytosis

Ruggero Caputo, A. Brezzi, G. Vaccari, S. Cavicchini, R. Gianotti

Research output: Contribution to journalArticle

Abstract

We describe the case of a 37-year-old male patient who in 1992 started developing a skin eruption characterized by dark red to red-yellow papulonodular lesions that showed no tendency to spontaneous resolution. Visceral organs were not involved and the lipid pattern was basically normal. Histological examination revealed an infiltrate in the mid and upper dermis mainly consisting of mononucleated and multinucleated histiocytes with an abundant eosinophilic cytoplasm and a ground glass appearance, admixed with numerous xanthomatized cells and Touton and foreign-body giant cells. Immunohistochemical studies showed positivity for CD68 and negativity for CD1a and S-100 protein, whereas at the electron microscopy level the only peculiar finding was the presence of many desmosome-like junctions. The authors believe this to be a borderline form between papular xanthoma and reticulohistiocytosis.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalDermatology
Volume205
Issue number2-3
DOIs
Publication statusPublished - 2002

Keywords

  • Non-Langerhans cell histiocytosis
  • Papular xanthoma
  • Progressive nodular histiocytosis
  • Reticulohistiocytosis

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Progressive histiocytosis: Description of a case of slow-course non-langerhans cell histiocytosis'. Together they form a unique fingerprint.

  • Cite this