Abstract
Common migraine (CM) is an evolutive disease characterized by a progressive increase in the number of attacks and a consequent reduction in the free periods, eventually reaching a state of continuous migraine with interparoxysmal headache (MIH). To evaluate the role of central pro-opiocortin-related peptides in the pathogenesis of the disease, cerebrospinal fluid (CSF) levels of β-lipotropin (β-LPH), β-endorphin (β-EP) and ACTH were measured in two groups of migraine sufferers with increasing severity of the disease (CM and MIH), and in healthy controls. ACTH values were similar in the 3 groups, while β-LPH levels were significantly lower (P <0.005) in patients affected by MIH (10.4 ± 8.6 fmol/ml) than in patients with CM (35.7 ± 8.3) and in controls (32.9 ± 15.33). β-EP levels were closely correlated with the severity of the disease: they decreased significantly from those found in healthy controls (86.1 ± 37 fmol/ml) to those of CM sufferers (38.5 ± 3.5; P <0.005) and showed a further significant fall (P <0.01) to the lowest levels which were found in MIH patients (14.8 ± 9.8). These data showing that the progressive evolution of migraine is concomitant with a progressive impairment in the CSF levels of β-EP, sustain the concept that non-organic central pain is related to a reduced activity of the neurons responsible for the CSF content of β-EP.
| Original language | English |
|---|---|
| Pages (from-to) | 127-133 |
| Number of pages | 7 |
| Journal | Pain |
| Volume | 18 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Neuroscience(all)
- Neurology
- Pharmacology
- Clinical Psychology
Cite this
Progressive impairment of CSF β-EP levels in migraine sufferers. / Genazzani, Andrea R.; Nappi, Giuseppe; Facchinetti, Fabio; Micieli, Giuseppe; Petraglia, Felice; Bono, Giuseppe; Monittola, Caterina; Savoldi, Faustino.
In: Pain, Vol. 18, No. 2, 1984, p. 127-133.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Progressive impairment of CSF β-EP levels in migraine sufferers
AU - Genazzani, Andrea R.
AU - Nappi, Giuseppe
AU - Facchinetti, Fabio
AU - Micieli, Giuseppe
AU - Petraglia, Felice
AU - Bono, Giuseppe
AU - Monittola, Caterina
AU - Savoldi, Faustino
PY - 1984
Y1 - 1984
N2 - Common migraine (CM) is an evolutive disease characterized by a progressive increase in the number of attacks and a consequent reduction in the free periods, eventually reaching a state of continuous migraine with interparoxysmal headache (MIH). To evaluate the role of central pro-opiocortin-related peptides in the pathogenesis of the disease, cerebrospinal fluid (CSF) levels of β-lipotropin (β-LPH), β-endorphin (β-EP) and ACTH were measured in two groups of migraine sufferers with increasing severity of the disease (CM and MIH), and in healthy controls. ACTH values were similar in the 3 groups, while β-LPH levels were significantly lower (P <0.005) in patients affected by MIH (10.4 ± 8.6 fmol/ml) than in patients with CM (35.7 ± 8.3) and in controls (32.9 ± 15.33). β-EP levels were closely correlated with the severity of the disease: they decreased significantly from those found in healthy controls (86.1 ± 37 fmol/ml) to those of CM sufferers (38.5 ± 3.5; P <0.005) and showed a further significant fall (P <0.01) to the lowest levels which were found in MIH patients (14.8 ± 9.8). These data showing that the progressive evolution of migraine is concomitant with a progressive impairment in the CSF levels of β-EP, sustain the concept that non-organic central pain is related to a reduced activity of the neurons responsible for the CSF content of β-EP.
AB - Common migraine (CM) is an evolutive disease characterized by a progressive increase in the number of attacks and a consequent reduction in the free periods, eventually reaching a state of continuous migraine with interparoxysmal headache (MIH). To evaluate the role of central pro-opiocortin-related peptides in the pathogenesis of the disease, cerebrospinal fluid (CSF) levels of β-lipotropin (β-LPH), β-endorphin (β-EP) and ACTH were measured in two groups of migraine sufferers with increasing severity of the disease (CM and MIH), and in healthy controls. ACTH values were similar in the 3 groups, while β-LPH levels were significantly lower (P <0.005) in patients affected by MIH (10.4 ± 8.6 fmol/ml) than in patients with CM (35.7 ± 8.3) and in controls (32.9 ± 15.33). β-EP levels were closely correlated with the severity of the disease: they decreased significantly from those found in healthy controls (86.1 ± 37 fmol/ml) to those of CM sufferers (38.5 ± 3.5; P <0.005) and showed a further significant fall (P <0.01) to the lowest levels which were found in MIH patients (14.8 ± 9.8). These data showing that the progressive evolution of migraine is concomitant with a progressive impairment in the CSF levels of β-EP, sustain the concept that non-organic central pain is related to a reduced activity of the neurons responsible for the CSF content of β-EP.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021360741&partnerID=8YFLogxK
U2 - 10.1016/0304-3959(84)90880-7
DO - 10.1016/0304-3959(84)90880-7
M3 - Article
C2 - 6324056
AN - SCOPUS:0021360741
VL - 18
SP - 127
EP - 133
JO - Pain
JF - Pain
SN - 0304-3959
IS - 2
ER -