Progressive impairment of CSF β-EP levels in migraine sufferers

Andrea R. Genazzani, Giuseppe Nappi, Fabio Facchinetti, Giuseppe Micieli, Felice Petraglia, Giuseppe Bono, Caterina Monittola, Faustino Savoldi

Research output: Contribution to journalArticle

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Abstract

Common migraine (CM) is an evolutive disease characterized by a progressive increase in the number of attacks and a consequent reduction in the free periods, eventually reaching a state of continuous migraine with interparoxysmal headache (MIH). To evaluate the role of central pro-opiocortin-related peptides in the pathogenesis of the disease, cerebrospinal fluid (CSF) levels of β-lipotropin (β-LPH), β-endorphin (β-EP) and ACTH were measured in two groups of migraine sufferers with increasing severity of the disease (CM and MIH), and in healthy controls. ACTH values were similar in the 3 groups, while β-LPH levels were significantly lower (P <0.005) in patients affected by MIH (10.4 ± 8.6 fmol/ml) than in patients with CM (35.7 ± 8.3) and in controls (32.9 ± 15.33). β-EP levels were closely correlated with the severity of the disease: they decreased significantly from those found in healthy controls (86.1 ± 37 fmol/ml) to those of CM sufferers (38.5 ± 3.5; P <0.005) and showed a further significant fall (P <0.01) to the lowest levels which were found in MIH patients (14.8 ± 9.8). These data showing that the progressive evolution of migraine is concomitant with a progressive impairment in the CSF levels of β-EP, sustain the concept that non-organic central pain is related to a reduced activity of the neurons responsible for the CSF content of β-EP.

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalPain
Volume18
Issue number2
DOIs
Publication statusPublished - 1984

Fingerprint

Migraine Disorders
Migraine without Aura
Cerebrospinal Fluid
Headache
Adrenocorticotropic Hormone
beta-Lipotropin
Endorphins
Pro-Opiomelanocortin
Neurons
Pain
Peptides

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neurology
  • Pharmacology
  • Clinical Psychology

Cite this

Genazzani, A. R., Nappi, G., Facchinetti, F., Micieli, G., Petraglia, F., Bono, G., ... Savoldi, F. (1984). Progressive impairment of CSF β-EP levels in migraine sufferers. Pain, 18(2), 127-133. https://doi.org/10.1016/0304-3959(84)90880-7

Progressive impairment of CSF β-EP levels in migraine sufferers. / Genazzani, Andrea R.; Nappi, Giuseppe; Facchinetti, Fabio; Micieli, Giuseppe; Petraglia, Felice; Bono, Giuseppe; Monittola, Caterina; Savoldi, Faustino.

In: Pain, Vol. 18, No. 2, 1984, p. 127-133.

Research output: Contribution to journalArticle

Genazzani, AR, Nappi, G, Facchinetti, F, Micieli, G, Petraglia, F, Bono, G, Monittola, C & Savoldi, F 1984, 'Progressive impairment of CSF β-EP levels in migraine sufferers', Pain, vol. 18, no. 2, pp. 127-133. https://doi.org/10.1016/0304-3959(84)90880-7
Genazzani AR, Nappi G, Facchinetti F, Micieli G, Petraglia F, Bono G et al. Progressive impairment of CSF β-EP levels in migraine sufferers. Pain. 1984;18(2):127-133. https://doi.org/10.1016/0304-3959(84)90880-7
Genazzani, Andrea R. ; Nappi, Giuseppe ; Facchinetti, Fabio ; Micieli, Giuseppe ; Petraglia, Felice ; Bono, Giuseppe ; Monittola, Caterina ; Savoldi, Faustino. / Progressive impairment of CSF β-EP levels in migraine sufferers. In: Pain. 1984 ; Vol. 18, No. 2. pp. 127-133.
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abstract = "Common migraine (CM) is an evolutive disease characterized by a progressive increase in the number of attacks and a consequent reduction in the free periods, eventually reaching a state of continuous migraine with interparoxysmal headache (MIH). To evaluate the role of central pro-opiocortin-related peptides in the pathogenesis of the disease, cerebrospinal fluid (CSF) levels of β-lipotropin (β-LPH), β-endorphin (β-EP) and ACTH were measured in two groups of migraine sufferers with increasing severity of the disease (CM and MIH), and in healthy controls. ACTH values were similar in the 3 groups, while β-LPH levels were significantly lower (P <0.005) in patients affected by MIH (10.4 ± 8.6 fmol/ml) than in patients with CM (35.7 ± 8.3) and in controls (32.9 ± 15.33). β-EP levels were closely correlated with the severity of the disease: they decreased significantly from those found in healthy controls (86.1 ± 37 fmol/ml) to those of CM sufferers (38.5 ± 3.5; P <0.005) and showed a further significant fall (P <0.01) to the lowest levels which were found in MIH patients (14.8 ± 9.8). These data showing that the progressive evolution of migraine is concomitant with a progressive impairment in the CSF levels of β-EP, sustain the concept that non-organic central pain is related to a reduced activity of the neurons responsible for the CSF content of β-EP.",
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AU - Petraglia, Felice

AU - Bono, Giuseppe

AU - Monittola, Caterina

AU - Savoldi, Faustino

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N2 - Common migraine (CM) is an evolutive disease characterized by a progressive increase in the number of attacks and a consequent reduction in the free periods, eventually reaching a state of continuous migraine with interparoxysmal headache (MIH). To evaluate the role of central pro-opiocortin-related peptides in the pathogenesis of the disease, cerebrospinal fluid (CSF) levels of β-lipotropin (β-LPH), β-endorphin (β-EP) and ACTH were measured in two groups of migraine sufferers with increasing severity of the disease (CM and MIH), and in healthy controls. ACTH values were similar in the 3 groups, while β-LPH levels were significantly lower (P <0.005) in patients affected by MIH (10.4 ± 8.6 fmol/ml) than in patients with CM (35.7 ± 8.3) and in controls (32.9 ± 15.33). β-EP levels were closely correlated with the severity of the disease: they decreased significantly from those found in healthy controls (86.1 ± 37 fmol/ml) to those of CM sufferers (38.5 ± 3.5; P <0.005) and showed a further significant fall (P <0.01) to the lowest levels which were found in MIH patients (14.8 ± 9.8). These data showing that the progressive evolution of migraine is concomitant with a progressive impairment in the CSF levels of β-EP, sustain the concept that non-organic central pain is related to a reduced activity of the neurons responsible for the CSF content of β-EP.

AB - Common migraine (CM) is an evolutive disease characterized by a progressive increase in the number of attacks and a consequent reduction in the free periods, eventually reaching a state of continuous migraine with interparoxysmal headache (MIH). To evaluate the role of central pro-opiocortin-related peptides in the pathogenesis of the disease, cerebrospinal fluid (CSF) levels of β-lipotropin (β-LPH), β-endorphin (β-EP) and ACTH were measured in two groups of migraine sufferers with increasing severity of the disease (CM and MIH), and in healthy controls. ACTH values were similar in the 3 groups, while β-LPH levels were significantly lower (P <0.005) in patients affected by MIH (10.4 ± 8.6 fmol/ml) than in patients with CM (35.7 ± 8.3) and in controls (32.9 ± 15.33). β-EP levels were closely correlated with the severity of the disease: they decreased significantly from those found in healthy controls (86.1 ± 37 fmol/ml) to those of CM sufferers (38.5 ± 3.5; P <0.005) and showed a further significant fall (P <0.01) to the lowest levels which were found in MIH patients (14.8 ± 9.8). These data showing that the progressive evolution of migraine is concomitant with a progressive impairment in the CSF levels of β-EP, sustain the concept that non-organic central pain is related to a reduced activity of the neurons responsible for the CSF content of β-EP.

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