Abstract
Development of the neuroendocrine hypothalamus is characterized by a precise series of morphogenetic milestones culminating in terminal differentiation of neurosecretory cell lineages. The homeobox-containing gene Orthopedia (Otp) is expressed in neurons giving rise to the paraventricular (PVN), supraoptic (SON), anterior periventricular (aPV), and arcuate (ARN) nuclei throughout their development. Homozygous Otp(-/-) mice die soon after birth and display progressive impairment of crucial neuroendocrine developmental events such as reduced cell proliferation, abnormal cell migration, and failure in terminal differentiation of the parvocellular and magnocellular neurons of the aPV, PVN, SON, and ARN. Moreover, our data provide evidence that Otp and Sim1, a bHLH-PAS transcription factor that directs terminal differentiation of the PVN, SON, and aPV, act in parallel and are both required to maintain Brn2 expression which, in turn, is required for neuronal cell lineages secreting oxytocin (OT), arginine vasopressin (AVP), and corticotropin-releasing hormone (CRH).
| Original language | English |
|---|---|
| Pages (from-to) | 2787-2800 |
| Number of pages | 14 |
| Journal | Genes and Development |
| Volume | 13 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 1999 |
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Keywords
- Cell migration
- Cell proliferation
- Neuroendocrine hypothalamus
- Orthopedia
- Terminal differentiation
ASJC Scopus subject areas
- Genetics
- Developmental Biology
Cite this
Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene. / Acampora, Dario; Postiglione, Maria Pia; Avantaggiato, Virginia; Di Bonito, Maria; Vaccarino, Flora M.; Michaud, Jacques; Simeone, Antonio.
In: Genes and Development, Vol. 13, No. 21, 1999, p. 2787-2800.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene
AU - Acampora, Dario
AU - Postiglione, Maria Pia
AU - Avantaggiato, Virginia
AU - Di Bonito, Maria
AU - Vaccarino, Flora M.
AU - Michaud, Jacques
AU - Simeone, Antonio
PY - 1999
Y1 - 1999
N2 - Development of the neuroendocrine hypothalamus is characterized by a precise series of morphogenetic milestones culminating in terminal differentiation of neurosecretory cell lineages. The homeobox-containing gene Orthopedia (Otp) is expressed in neurons giving rise to the paraventricular (PVN), supraoptic (SON), anterior periventricular (aPV), and arcuate (ARN) nuclei throughout their development. Homozygous Otp(-/-) mice die soon after birth and display progressive impairment of crucial neuroendocrine developmental events such as reduced cell proliferation, abnormal cell migration, and failure in terminal differentiation of the parvocellular and magnocellular neurons of the aPV, PVN, SON, and ARN. Moreover, our data provide evidence that Otp and Sim1, a bHLH-PAS transcription factor that directs terminal differentiation of the PVN, SON, and aPV, act in parallel and are both required to maintain Brn2 expression which, in turn, is required for neuronal cell lineages secreting oxytocin (OT), arginine vasopressin (AVP), and corticotropin-releasing hormone (CRH).
AB - Development of the neuroendocrine hypothalamus is characterized by a precise series of morphogenetic milestones culminating in terminal differentiation of neurosecretory cell lineages. The homeobox-containing gene Orthopedia (Otp) is expressed in neurons giving rise to the paraventricular (PVN), supraoptic (SON), anterior periventricular (aPV), and arcuate (ARN) nuclei throughout their development. Homozygous Otp(-/-) mice die soon after birth and display progressive impairment of crucial neuroendocrine developmental events such as reduced cell proliferation, abnormal cell migration, and failure in terminal differentiation of the parvocellular and magnocellular neurons of the aPV, PVN, SON, and ARN. Moreover, our data provide evidence that Otp and Sim1, a bHLH-PAS transcription factor that directs terminal differentiation of the PVN, SON, and aPV, act in parallel and are both required to maintain Brn2 expression which, in turn, is required for neuronal cell lineages secreting oxytocin (OT), arginine vasopressin (AVP), and corticotropin-releasing hormone (CRH).
KW - Cell migration
KW - Cell proliferation
KW - Neuroendocrine hypothalamus
KW - Orthopedia
KW - Terminal differentiation
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UR - http://www.scopus.com/inward/citedby.url?scp=0032702290&partnerID=8YFLogxK
U2 - 10.1101/gad.13.21.2787
DO - 10.1101/gad.13.21.2787
M3 - Article
C2 - 10557207
AN - SCOPUS:0032702290
VL - 13
SP - 2787
EP - 2800
JO - Genes and Development
JF - Genes and Development
SN - 0890-9369
IS - 21
ER -