Progressive multifocal leukoencephalopathy in a patient with Franklin disease and hypogammaglobulinemia

Giorgio Tasca; Raffaele Iorio; Umberto Basile; Libero Lauriola; Raffaele Tartaglione; Massimiliano Mirabella; Enzo Ricci; Mario Sabatelli

doi:10.1016/j.jns.2009.04.035

Progressive multifocal leukoencephalopathy in a patient with Franklin disease and hypogammaglobulinemia

Giorgio Tasca, Raffaele Iorio, Umberto Basile, Libero Lauriola, Raffaele Tartaglione, Massimiliano Mirabella, Enzo Ricci, Mario Sabatelli

Research output: Contribution to journal › Article › peer-review

Abstract

We report an association between histologically confirmed progressive multifocal leukoencephalopathy (PML) and an extremely rare humoral immunodeficiency disease, Franklin disease. In our patient, clinical presentation has been typical and prompted us, together with radiological findings, to perform a brain biopsy to confirm the diagnosis even if there was no evidence of any other risk factor except hypogammaglobulinemia. We suggest that PML should be suspected in patients in whom immunosuppression is not obvious (i.e. not only in the setting of HIV infection or disseminated end-stage lymphomas) and involves defects in humoral immunity.

Original language	English
Pages (from-to)	203-204
Number of pages	2
Journal	Journal of the Neurological Sciences
Volume	284
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2009.04.035
Publication status	Published - Sep 15 2009

Keywords

Franklin disease
Hypogammaglobulinemia
Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

Clinical Neurology
Neurology

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Progressive multifocal leukoencephalopathy in a patient with Franklin disease and hypogammaglobulinemia. / Tasca, Giorgio ; Iorio, Raffaele; Basile, Umberto; Lauriola, Libero; Tartaglione, Raffaele; Mirabella, Massimiliano; Ricci, Enzo; Sabatelli, Mario.

In: Journal of the Neurological Sciences, Vol. 284, No. 1-2, 15.09.2009, p. 203-204.

Research output: Contribution to journal › Article › peer-review

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