Progressive multifocal leukoencephalopathy in a patient with Franklin disease and hypogammaglobulinemia

Giorgio Tasca, Raffaele Iorio, Umberto Basile, Libero Lauriola, Raffaele Tartaglione, Massimiliano Mirabella, Enzo Ricci, Mario Sabatelli

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report an association between histologically confirmed progressive multifocal leukoencephalopathy (PML) and an extremely rare humoral immunodeficiency disease, Franklin disease. In our patient, clinical presentation has been typical and prompted us, together with radiological findings, to perform a brain biopsy to confirm the diagnosis even if there was no evidence of any other risk factor except hypogammaglobulinemia. We suggest that PML should be suspected in patients in whom immunosuppression is not obvious (i.e. not only in the setting of HIV infection or disseminated end-stage lymphomas) and involves defects in humoral immunity.

Original languageEnglish
Pages (from-to)203-204
Number of pages2
JournalJournal of the Neurological Sciences
Volume284
Issue number1-2
DOIs
Publication statusPublished - Sep 15 2009

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Heavy Chain Disease
Progressive Multifocal Leukoencephalopathy
Agammaglobulinemia
Humoral Immunity
Immunosuppression
HIV Infections
Lymphoma
Biopsy
Brain

Keywords

  • Franklin disease
  • Hypogammaglobulinemia
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Progressive multifocal leukoencephalopathy in a patient with Franklin disease and hypogammaglobulinemia. / Tasca, Giorgio; Iorio, Raffaele; Basile, Umberto; Lauriola, Libero; Tartaglione, Raffaele; Mirabella, Massimiliano; Ricci, Enzo; Sabatelli, Mario.

In: Journal of the Neurological Sciences, Vol. 284, No. 1-2, 15.09.2009, p. 203-204.

Research output: Contribution to journalArticle

Tasca, Giorgio ; Iorio, Raffaele ; Basile, Umberto ; Lauriola, Libero ; Tartaglione, Raffaele ; Mirabella, Massimiliano ; Ricci, Enzo ; Sabatelli, Mario. / Progressive multifocal leukoencephalopathy in a patient with Franklin disease and hypogammaglobulinemia. In: Journal of the Neurological Sciences. 2009 ; Vol. 284, No. 1-2. pp. 203-204.
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