Progressive multifocal leukoencephalopathy in an adult patient with ICF syndrome

Monica Colucci, Leonardo Cocito, Elisabetta Capello, Gian Luigi Mancardi, Carlo Serrati, Paola Cinque, Angelo Schenone

Research output: Contribution to journalArticle

Abstract

We report on a patient affected by ICF syndrome (immunodeficiency, centromeric instability of chromosomes 1, 9 and 16 and facial dysmorphism), who presented with slowing in mentation, mild right hemiparesis and focal motor seizures. MRI study of the brain suggested a diagnosis of progressive multifocal leukoencephalopathy (PML), which was confirmed by JC virus DNA detection on CSF by polymerase chain reaction (PCR). This is a unique case of adult infective neurological complication described in ICF Syndrome.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalJournal of the Neurological Sciences
Volume217
Issue number1
DOIs
Publication statusPublished - Jan 15 2004

Fingerprint

Progressive Multifocal Leukoencephalopathy
Seizures
JC Virus
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 1
Paresis
Polymerase Chain Reaction
DNA
Brain
Variable Immunodeficiency syndrome

Keywords

  • ICF syndrome
  • JC virus
  • Progressive Multifocal Leukoencephalopathy

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Progressive multifocal leukoencephalopathy in an adult patient with ICF syndrome. / Colucci, Monica; Cocito, Leonardo; Capello, Elisabetta; Mancardi, Gian Luigi; Serrati, Carlo; Cinque, Paola; Schenone, Angelo.

In: Journal of the Neurological Sciences, Vol. 217, No. 1, 15.01.2004, p. 107-110.

Research output: Contribution to journalArticle

Colucci, M, Cocito, L, Capello, E, Mancardi, GL, Serrati, C, Cinque, P & Schenone, A 2004, 'Progressive multifocal leukoencephalopathy in an adult patient with ICF syndrome', Journal of the Neurological Sciences, vol. 217, no. 1, pp. 107-110. https://doi.org/10.1016/j.jns.2003.08.009
Colucci, Monica ; Cocito, Leonardo ; Capello, Elisabetta ; Mancardi, Gian Luigi ; Serrati, Carlo ; Cinque, Paola ; Schenone, Angelo. / Progressive multifocal leukoencephalopathy in an adult patient with ICF syndrome. In: Journal of the Neurological Sciences. 2004 ; Vol. 217, No. 1. pp. 107-110.
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