Progressive multifocal leukoencephalopathy in an adult patient with ICF syndrome

Monica Colucci, Leonardo Cocito, Elisabetta Capello, Gian Luigi Mancardi, Carlo Serrati, Paola Cinque, Angelo Schenone

Research output: Contribution to journalArticlepeer-review

Abstract

We report on a patient affected by ICF syndrome (immunodeficiency, centromeric instability of chromosomes 1, 9 and 16 and facial dysmorphism), who presented with slowing in mentation, mild right hemiparesis and focal motor seizures. MRI study of the brain suggested a diagnosis of progressive multifocal leukoencephalopathy (PML), which was confirmed by JC virus DNA detection on CSF by polymerase chain reaction (PCR). This is a unique case of adult infective neurological complication described in ICF Syndrome.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalJournal of the Neurological Sciences
Volume217
Issue number1
DOIs
Publication statusPublished - Jan 15 2004

Keywords

  • ICF syndrome
  • JC virus
  • Progressive Multifocal Leukoencephalopathy

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

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