Progressive necrotic myelopathy as a paraneoplastic syndrome: Report of a case and some pathogenetic considerations

G. Grignani, P. G. Gobbi, G. Piccolo, D. Bertoloni, A. Rossi, C. Pieresca, M. C. Legnani, E. Ascari

Research output: Contribution to journalArticlepeer-review

Abstract

Progressive necrotic myelopathy is a syndrome characterized by a spotty necrotic degeneration of the whole spinal cord in both anterior and posterior horns. This syndrome was recorded in a man suffering from a lymphoplasmatocytoid lymphoma. Whilst the usual evolution of this neurological syndrome is inexorably fatal, our case had a better outcome, due to the good response of the neoplasm to therapy. Progressive necrotic myelopathy is an uncommon complication of cancer, but it is probably incorrectly recognized in a number of cases. Two possible pathogenetic hypotheses are suggested: an autoimmune or an infective mechanism.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalJournal of Internal Medicine
Volume231
Issue number1
Publication statusPublished - 1992

Keywords

  • Lymphoma
  • Necrotic myelopathy
  • Paraneoplastic syndrome

ASJC Scopus subject areas

  • Internal Medicine

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