Translated title of the contribution: Progressive supranuclear palsy review

M. Matteis, R. Vizioli

Research output: Contribution to journalReview articlepeer-review


Progressive Sopranuclear Palsy (P.S.P.) is a disease not easy to diagnose because either it does not occur often in the common neurological practice or if occurs it is easily confused with other deceases. In the present work the Authors review the literature concerning P.S.P. from its first identification as a distinct anatomoclinic entity 26 years ago by Steele, Richardson, Olszewski, untill today to the effort to delineate the present state of knowledge. The authors have mentioned the main etiopathogenic and fisiopathogolic hypothesis, the recent epidemiological researchs the conclusion of anamopathological and biochemical studies, those last ones concerning specific abnormalities of neurotrasmettitors. The clinical pattern considered typical of the disease is revealed by specific analysis of the single symptoms, keeping in mind the large series of atypical cases and symptoms previously published. They have also considered the biological and instrumental investigations used for diagnosis and the different treatments trend in order to stop the inexorable progressive course of illness. Furthermore the AA present a case of P.S.P. with depression as the first symptom. It remained the only clinical feature during 3 years before the appearance of neurological symptoms of the disease. Considering the ever increasing number of reported cases of Parkinson disease that begin with depression including our study of P.S.P. and others works previously published, the authors suggest to name if for every depression followed by extrapiramidal pathology 'extrapiramidal depression' an entity to be added to the endogenous, reactive and bipolar depression.

Translated title of the contributionProgressive supranuclear palsy review
Original languageItalian
Pages (from-to)67-127
Number of pages61
JournalNeurologia Psichiatria Scienze Umane
Issue number1
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology


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