Progressive supranuclear palsy with hypertrophy of the olives - An immunocytochemical study of the cytoskeleton of argyrophilic neurons

G. Giaccone, F. Tagliavini, J. S. Street, B. Ghetti, O. Bugiani

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In a patient with progressive supranuclear palsy (PSP) and hypertrophy of the olives, neurons with different forms of argyrophilic degeneration were detected by means of Bodian's silver staining method, i.e., neurofibrillary tangle-bearing neurons in the basal ganglia and brain stem, blalloned argyrophilic neurons in the brain stem, and hypertrophied neurons in the olives. In these cells, the cytoskeleton was investigated to ascertain whether neurons with different cytoskeletal changes contained phosphorylated neurofilaments (P-Nf) in the perikaryon. This study, carried out using two monoclonal antibodies that recognize phosphorylated epitopes of the neurofilament high molecular weight subunits, showed that hypertrophied olivary neurons, most ballooned neurons and a small aliquot of tangle-bearing neurons were labelled. The immunostaining of hypertrophied and ballooned neurons was localized in the whole perikaryon and dendrites, whereas that of tangle-bearing neurons was confined to the tangle. These findings were reproduced in five additional patients (one with hypertrophy of the olives, four with PSP) and demonstrated that, in PSP, the mechanism responsible for tangle formation does not affect the ability of neurons to accumulate P-Nf. This fact suggested that perikaryonal P-Nf accumulation is likely to be part of the cell reaction to abnormal conditions affecting the neuronal cytoskeleton.

Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalActa Neuropathologica
Volume77
Issue number1
DOIs
Publication statusPublished - Jan 1988

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Progressive Supranuclear Palsy
Olea
Cytoskeleton
Hypertrophy
Neurons
Intermediate Filaments
Brain Stem
Neurofibrillary Tangles
Silver Staining
Dendrites
Basal Ganglia
Epitopes
Molecular Weight
Monoclonal Antibodies

Keywords

  • Hypertrophy of the olives
  • Immunocytochemistry
  • Neurofilaments
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Progressive supranuclear palsy with hypertrophy of the olives - An immunocytochemical study of the cytoskeleton of argyrophilic neurons. / Giaccone, G.; Tagliavini, F.; Street, J. S.; Ghetti, B.; Bugiani, O.

In: Acta Neuropathologica, Vol. 77, No. 1, 01.1988, p. 14-20.

Research output: Contribution to journalArticle

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