Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma

Jason A. Hoffman, Enrico Giraudo, Mallika Singh, Lianglin Zhang, Masahiro Inoue, Kimmo Porkka, Douglas Hanahan, Erkki Ruoslahti

Research output: Contribution to journalArticle

Abstract

Phage display was used to identify homing peptides for blood vessels in a mouse model of HPV16-induced epidermal carcinogenesis. One peptide, CSRPRRSEC, recognized the neovasculature in dysplastic skin but not in carcinomas. Two other peptides, with the sequences CGKRK and CDTRL, preferentially homed to neovasculature in tumors and, to a lesser extent, premalignant dysplasias. The peptides did not home to vessels in normal skin, other normal organs, or the stages in pancreatic islet carcinogenesis in another mouse model. The CGKRK peptide may recognize heparan sulfates in tumor vessels. The dysplasia-homing peptide is identical to a loop in kallikrein-9 and may bind a kallikrein inhibitor or substrate. Thus, characteristics of the angiogenic vasculature distinguish premalignant and malignant stages of skin tumorigenesis.

Original languageEnglish
Pages (from-to)383-391
Number of pages9
JournalCancer Cell
Volume4
Issue number5
DOIs
Publication statusPublished - Nov 2003

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

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  • Cite this

    Hoffman, J. A., Giraudo, E., Singh, M., Zhang, L., Inoue, M., Porkka, K., Hanahan, D., & Ruoslahti, E. (2003). Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma. Cancer Cell, 4(5), 383-391. https://doi.org/10.1016/S1535-6108(03)00273-3