Prohibitin 2: At a communications crossroads

Alberto Bavelloni, Manuela Piazzi, Mirco Raffini, Irene Faenza, William L. Blalock

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract Prohibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of cellular proliferation. Since then PHBs have been found to have a significant role in transcription, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism, placing these proteins among the key regulators of pathologies such as cancer, neuromuscular degeneration, and other metabolic diseases. The human genome encodes two PHB proteins, prohibitin 1 (PHB1) and prohibitin 2 (PHB2), which function not only as a heterodimeric complex, but also independently. While many previous reviews have focused on the better characterized prohibitin, PHB1, this review focuses on PHB2 and new data concerning its cellular functions both in complex with PHB1 and independent of PHB1.

Original languageEnglish
Pages (from-to)239-254
Number of pages16
JournalIUBMB Life
Volume67
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • AKT
  • Alzheimer's
  • CaMK IV
  • cancer
  • diabetes
  • differentiation
  • gene regulation
  • inflammation
  • mitochondria
  • myositis
  • nucleus
  • plasma membrane receptors
  • prohibitin
  • stress
  • transcription

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

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