TY - JOUR
T1 - Proinflammatory cytokines and antiskin autoantibodies in patients with inherited epidermolysis bullosa
AU - Annicchiarico, Giuseppina
AU - Morgese, Maria Grazia
AU - Esposito, Susanna
AU - Lopalco, Giuseppe
AU - Lattarulo, Michele
AU - Tampoia, Marilina
AU - Bonamonte, Domenico
AU - Brunetti, Luigia
AU - Vitale, Antonio
AU - Lapadula, Giovanni
AU - Cantarini, Luca
AU - Iannone, Florenzo
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Epidermolysis bullosa (EB) is a rare disorder characterized by inherited skin adhesion defects with abnormal disruption of the epidermal'dermal junction in response to mechanical trauma. Our aim was to investigate a set of cytokine levels in serum samples from patients suffering from epidermolysis bullosa simplex (EBS), dystrophic epidermolysis bullosa (DEB), and healthy controls (HCs), exploring their potential correlations with antiskin autoantibody titers and disease activity. Forty patients afferent to the Dermatological Ward of Bari City Hospital and 9 HCs were enrolled and subdivided according to the dystrophic (DEB) and simplex forms (EBS). We found a significant increase in interleukin (IL)-1b plasmatic levels of DEB (P'0.0224) and EBS (P'0.0465) patients compared to HCs; IL-6 levels were significantly higher in DEB than in EBS patients (P'0.0004) or HCs (P'0.0474); IL-2 levels were significantly increased in DEB compared with EBS (P'0.0428). Plasmatic tumor necrosis factor-b and interferon-g were higher in DEB patients than in HCs (P'0.0448 and 0.0229). Conversely, tumor necrosis factor-A was significantly decreased in DEB (P'0.0034). IL-5 correlated with anti-BP180 (r'-0.5018, P'0.0338), anti-BP230 (r'-0.6097, P'0.0122), and anticollagen VII (r'-0.5166, P'0.0405) autoantibodies; interferon-g correlated with anti-BP180 (r'0.9633, P
AB - Epidermolysis bullosa (EB) is a rare disorder characterized by inherited skin adhesion defects with abnormal disruption of the epidermal'dermal junction in response to mechanical trauma. Our aim was to investigate a set of cytokine levels in serum samples from patients suffering from epidermolysis bullosa simplex (EBS), dystrophic epidermolysis bullosa (DEB), and healthy controls (HCs), exploring their potential correlations with antiskin autoantibody titers and disease activity. Forty patients afferent to the Dermatological Ward of Bari City Hospital and 9 HCs were enrolled and subdivided according to the dystrophic (DEB) and simplex forms (EBS). We found a significant increase in interleukin (IL)-1b plasmatic levels of DEB (P'0.0224) and EBS (P'0.0465) patients compared to HCs; IL-6 levels were significantly higher in DEB than in EBS patients (P'0.0004) or HCs (P'0.0474); IL-2 levels were significantly increased in DEB compared with EBS (P'0.0428). Plasmatic tumor necrosis factor-b and interferon-g were higher in DEB patients than in HCs (P'0.0448 and 0.0229). Conversely, tumor necrosis factor-A was significantly decreased in DEB (P'0.0034). IL-5 correlated with anti-BP180 (r'-0.5018, P'0.0338), anti-BP230 (r'-0.6097, P'0.0122), and anticollagen VII (r'-0.5166, P'0.0405) autoantibodies; interferon-g correlated with anti-BP180 (r'0.9633, P
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U2 - 10.1097/MD.0000000000001528
DO - 10.1097/MD.0000000000001528
M3 - Article
AN - SCOPUS:84947940124
VL - 94
SP - e1528
JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
SN - 0025-7974
IS - 42
ER -