Proinflammatory cytokines and antiskin autoantibodies in patients with inherited epidermolysis bullosa

Giuseppina Annicchiarico, Maria Grazia Morgese, Susanna Esposito, Giuseppe Lopalco, Michele Lattarulo, Marilina Tampoia, Domenico Bonamonte, Luigia Brunetti, Antonio Vitale, Giovanni Lapadula, Luca Cantarini, Florenzo Iannone

Research output: Contribution to journalArticlepeer-review

Abstract

Epidermolysis bullosa (EB) is a rare disorder characterized by inherited skin adhesion defects with abnormal disruption of the epidermal'dermal junction in response to mechanical trauma. Our aim was to investigate a set of cytokine levels in serum samples from patients suffering from epidermolysis bullosa simplex (EBS), dystrophic epidermolysis bullosa (DEB), and healthy controls (HCs), exploring their potential correlations with antiskin autoantibody titers and disease activity. Forty patients afferent to the Dermatological Ward of Bari City Hospital and 9 HCs were enrolled and subdivided according to the dystrophic (DEB) and simplex forms (EBS). We found a significant increase in interleukin (IL)-1b plasmatic levels of DEB (P'0.0224) and EBS (P'0.0465) patients compared to HCs; IL-6 levels were significantly higher in DEB than in EBS patients (P'0.0004) or HCs (P'0.0474); IL-2 levels were significantly increased in DEB compared with EBS (P'0.0428). Plasmatic tumor necrosis factor-b and interferon-g were higher in DEB patients than in HCs (P'0.0448 and 0.0229). Conversely, tumor necrosis factor-A was significantly decreased in DEB (P'0.0034). IL-5 correlated with anti-BP180 (r'-0.5018, P'0.0338), anti-BP230 (r'-0.6097, P'0.0122), and anticollagen VII (r'-0.5166, P'0.0405) autoantibodies; interferon-g correlated with anti-BP180 (r'0.9633, P

Original languageEnglish
Pages (from-to)e1528
JournalMedicine (United States)
Volume94
Issue number42
DOIs
Publication statusPublished - Oct 1 2015

ASJC Scopus subject areas

  • Medicine(all)

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