TY - JOUR
T1 - Proinflammatory Cytokines Predict Brain Metabolite Concentrations in the Anterior Cingulate Cortex of Patients With Bipolar Disorder
AU - Poletti, Sara
AU - Mazza, Mario Gennaro
AU - Vai, Benedetta
AU - Lorenzi, Cristina
AU - Colombo, Cristina
AU - Benedetti, Francesco
N1 - Funding Information:
This work was supported by the European Union H2020 EU.3.1.1 grant 754740 MOODSTRATIFICATION (PI, FB) and the Italian Ministry of Health, grant RF-2011-02350980 (PI, FB). BV was supported by Fondazione Centro San Raffaele.
Publisher Copyright:
© Copyright © 2020 Poletti, Mazza, Vai, Lorenzi, Colombo and Benedetti.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12/8
Y1 - 2020/12/8
N2 - Bipolar disorder (BD) is a severe psychiatric illness characterized by abnormalities in the immune/inflammatory function and in brain metabolism. Evidences suggest that inflammation may affect the levels of brain metabolites as measured by single-proton magnetic resonance spectroscopy (1H-MRS). The aim of the study was to investigate whether a wide panel of inflammatory markers (i.e., cytokines, chemokines, and growth factors) can predict brain metabolite concentrations of glutamate, myo-inositol, N-acetylaspartate, and glutathione in a sample of 63 bipolar patients and 49 healthy controls. Three cytokines influenced brain metabolite concentrations: IL-9 positively predicts glutamate, IL-1β positively predicts Myo-inositol, and CCL5 positively predicts N-acetylaspartate concentrations. Furthermore, patients showed higher concentrations of glutamate, Myo-inositol, and glutathione and lower concentrations of N-acetylaspartate in respect to healthy controls. Our results confirm that inflammation in BD alters brain metabolism, through mechanisms possibly including the production of reactive oxygen species and glia activation.
AB - Bipolar disorder (BD) is a severe psychiatric illness characterized by abnormalities in the immune/inflammatory function and in brain metabolism. Evidences suggest that inflammation may affect the levels of brain metabolites as measured by single-proton magnetic resonance spectroscopy (1H-MRS). The aim of the study was to investigate whether a wide panel of inflammatory markers (i.e., cytokines, chemokines, and growth factors) can predict brain metabolite concentrations of glutamate, myo-inositol, N-acetylaspartate, and glutathione in a sample of 63 bipolar patients and 49 healthy controls. Three cytokines influenced brain metabolite concentrations: IL-9 positively predicts glutamate, IL-1β positively predicts Myo-inositol, and CCL5 positively predicts N-acetylaspartate concentrations. Furthermore, patients showed higher concentrations of glutamate, Myo-inositol, and glutathione and lower concentrations of N-acetylaspartate in respect to healthy controls. Our results confirm that inflammation in BD alters brain metabolism, through mechanisms possibly including the production of reactive oxygen species and glia activation.
KW - glutamate
KW - inflammation
KW - mood disorder
KW - myo-inositol
KW - spectroscopy
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U2 - 10.3389/fpsyt.2020.590095
DO - 10.3389/fpsyt.2020.590095
M3 - Article
AN - SCOPUS:85098061371
VL - 11
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
SN - 1664-0640
M1 - 590095
ER -