Prolactin may be increased in newly diagnosed celiac children and adolescents and decreases after 6 months of gluten-free diet

Maurizio Delvecchio, Maria Felicia Faienza, Antonella Lonero, Vincenzo Rutigliano, Ruggiero Francavilla, Luciano Cavallo

Research output: Contribution to journalArticle

Abstract

Background/Aims: Prolactin (PRL) is produced by the anterior pituitary gland. It exerts its role on the breast gland but also plays a modulatory role in autoimmune mechanisms. Celiac disease (CD) is a gluten-sensitive autoimmune enteropathy sometimes associated with autoimmune endocrinopathies. No data on PRL levels in CD patients are available at diagnosis, and no conclusive data are reported. Methods: We aimed to evaluate PRL secretion in newly diagnosed CD pediatric patients and, in the case of hyperprolactinemia, any changes in its levels while the patients were on a gluten-free diet (GFD). We recruited 67 patients and 39 healthy controls. Results: PRL was statistically higher in the CD patients (13.5 ± 9.2 ng/ml) than in the controls (8.5 ± 5.0 ng/ml). In the CD group, PRL was inversely correlated with the age at diagnosis (r = -0.326; p = 0.007). In patients with hyperprolactinemia at diagnosis, PRL decreased after 6 months of GFD. Conclusion: This paper confirms that PRL may be increased at diagnosis of CD and shows, for the first time, that it decreases after a short course of GFD. Changes in the levels of inflammatory cytokines in CD may account for changes in PRL levels. Younger patients seem more prone to develop hyperprolactinemia than older ones.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalHormone Research in Paediatrics
Volume81
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Autoimmunity
  • Celiac disease
  • Childhood
  • Gluten-free diet
  • Prolactin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

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