The present study deals witii the effects of long-lasting heroin addiction on the basal levels of prolactin and its response to stimulation with TRH (500 μg i.v.) or sulpiride (100 mg i.m.). Assays were done in 17 male heroin addicts, aged 18-40 years, with a history of addiction of heroin only lasting from 8 months to 4 years and a daily intravenous intake between 200 and 2,500 mg. The presence of heroin in the urine was demonstrated. The results obtained show basal hyperprolactinemia in 7 patients, with a blunted response to either TRH or sulpiride stimulation in 4 of these. It is suggested that heroin addiction induces a dopaminergic blockade responsible for hormonal impairments.
- Heroin addiction
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Neuropsychology and Physiological Psychology