Proliferating cell nuclear antigen (PCNA) as a prognostic factor for colorectal cancer

D. Kovac, M. Rubinic, M. Krasevic, S. Krizanac, M. Petrovecki, D. Stimac, M. Melato

Research output: Contribution to journalArticle

Abstract

PCNA (proliferating cell nuclear antigen) is a cell cycle related protein that is maximally elevated in late G1 and S-phase of proliferating cells. 114 biopsy specimens of colorectal cancer were immunolabeled with PC 10 which specifically recognizes PCNA; Dukes' staging and histological grading were estimated for each case. All patients were followed-up for at least 60 months or to death. All data were analysed by the computer program NCSS (Number Cruncher Statistical System). According to the results, PCNA-index may be considered an independent prognostic factor for colorectal cancer; it may also be helpful in supporting the therapeutic strategies based only on Dukes' stage.

Original languageEnglish
Pages (from-to)2301-2302
Number of pages2
JournalAnticancer Research
Volume15
Issue number5 B
Publication statusPublished - 1995

Keywords

  • Colorectal neoplasms
  • Immunohistochemistry
  • Prognosis
  • Proliferating cell nuclear antigen (PCNA)

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Kovac, D., Rubinic, M., Krasevic, M., Krizanac, S., Petrovecki, M., Stimac, D., & Melato, M. (1995). Proliferating cell nuclear antigen (PCNA) as a prognostic factor for colorectal cancer. Anticancer Research, 15(5 B), 2301-2302.