Abstract
A kinetic study was performed on leukemic blasts from patients with acute myeloid leukemia, separated into 2 subpopulations by a specific density gradient. The growth curve and the [3H]-thymidine uptake were simultaneously analyzed. While cumulative nucleotide uptake fitted with the growth kinetics in the low-density fraction, such a concordance was not found in the high-density subpopulation. That indicated the occurrence of simultaneous growth and loss in the high density fraction, which could not be evaluated by a simple numerical determination.
Original language | English |
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Pages (from-to) | 245-247 |
Number of pages | 3 |
Journal | Experientia |
Volume | 44 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 1988 |
Keywords
- Acute myelogenous leukemia
- cell loss
- cell subpopulations
- kinetics in culture
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)