Proliferation and cell loss of human leukemic cell subpopulations in liquid culture

P. A. Bernabei, F. C. Agostino, R. Bezzini, R. Saccardi, V. Gattei, V. Santini, M. Casini, P. Rossi Ferrini

Research output: Contribution to journalArticle

Abstract

A kinetic study was performed on leukemic blasts from patients with acute myeloid leukemia, separated into 2 subpopulations by a specific density gradient. The growth curve and the [3H]-thymidine uptake were simultaneously analyzed. While cumulative nucleotide uptake fitted with the growth kinetics in the low-density fraction, such a concordance was not found in the high-density subpopulation. That indicated the occurrence of simultaneous growth and loss in the high density fraction, which could not be evaluated by a simple numerical determination.

Original languageEnglish
Pages (from-to)245-247
Number of pages3
JournalExperientia
Volume44
Issue number3
DOIs
Publication statusPublished - Mar 1988

    Fingerprint

Keywords

  • Acute myelogenous leukemia
  • cell loss
  • cell subpopulations
  • kinetics in culture

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bernabei, P. A., Agostino, F. C., Bezzini, R., Saccardi, R., Gattei, V., Santini, V., Casini, M., & Rossi Ferrini, P. (1988). Proliferation and cell loss of human leukemic cell subpopulations in liquid culture. Experientia, 44(3), 245-247. https://doi.org/10.1007/BF01941723