Proliferative activity, angiogenesis, and necrosis in peripheral nerve sheath tumors: A quantitative evaluation for prognosis

Clelia Miracco, Maria Cristina Montesco, Rosa Santopietro, Donatella Spina, E. S G D'Amore, Piero Tosi, Vito Ninfo

Research output: Contribution to journalArticlepeer-review

Abstract

Malignant peripheral nerve sheath tumors (MPN-STs) are distinguished from a control group of typical benign schwannomas and neurofibromas on the basis of a set of quantitatively evaluated parameters, i.e., the cell density; the number of mitoses and apoptotic bodies; the nuclear area and shape; the number and absolute and relative areas of silver-staining nucleolar organizer regions; necrosis; and angiogenesis. Only the extent of tumor necrosis, the mitotic rate, and the parameters related to silver-staining nucleolar organizer regions discriminate between less aggressive MPNSTs (disease-free patients after 4 years of follow-up) and more aggressive MPNSTs (with recurrences or metastases during the first 4 years of follow-up).

Original languageEnglish
Pages (from-to)1108-1117
Number of pages10
JournalModern Pathology
Volume9
Issue number12
Publication statusPublished - Dec 1996

Keywords

  • AgNOR
  • Apoptosis
  • Mitosis
  • Morphometry
  • Neovascularization
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint

Dive into the research topics of 'Proliferative activity, angiogenesis, and necrosis in peripheral nerve sheath tumors: A quantitative evaluation for prognosis'. Together they form a unique fingerprint.

Cite this