Proliferative activity (Ki-67), WT p53, Bcl-2 expression and their relationship to the tumor grade, in invasive ductal breast carcinomas

Alexandra Kalogeraki, F. Garbagnati, M. Santinami, O. Zoras

Research output: Contribution to journalArticle

Abstract

To study the relationship between the expressions of Ki-67, WT p53, Bcl-2 proteins and tumor grade, on fine needle aspiration biopsies (FNABs), in patients with invasive ductal breast carcinomas. One hundred (100) FNABs were performed from the same number of female patients, diagnosed cytologically and confirmed histologically after oncectomy. The same cases were studied immunocytochemically using the monoclonal antibodies Ki-67, WT p53 and Bcl-2 by the alkaline phosphatase (APAAP) method and correlated to the nuclear and histological grade of the tumors. An association and a relationship was found between the grade of the tumors and the immunoexpression of Ki-67, WT p53 and Bcl-2 proteins (p

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalIn Vivo
Volume16
Issue number2
Publication statusPublished - 2002

Keywords

  • Bcl-2
  • Ductal breast carcinoma
  • FNAB
  • Ki-67
  • WT p53

ASJC Scopus subject areas

  • Medicine(all)

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