Proliferative effect of dexamethasone on a human glioblastoma cell line (HU 197) is mediated by glucocorticoid receptors

C. Zibera, N. Gibelli, G. Butti, P. Pedrazzoli, M. Carbone, L. Magrassi, G. R. Della Cuna

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship between Dexamethasone proliferative activity and the presence of glucocorticoid receptors was studied on a human glioblastoma cell line (HU 197). For this purpose, the 17β-Carboxamide steroid DXB, a glucocorticoid antagonist that competes with Dexamethasone for binding to the intracellular glucocorticoid receptor but does not trigger the glucorticoid effect, was used. Concurrent treatments with Dexamethasone and DXB caused an inhibition of the proliferative effect obtained by Dexamethasone. The results obtained demonstrated that the Dexamethasone activity on cell proliferation is a specific receptor-mediated effect.

Original languageEnglish
Pages (from-to)1571-1574
Number of pages4
JournalAnticancer Research
Volume12
Issue number5
Publication statusPublished - 1992

Keywords

  • Cell proliferation
  • Dexamethasone
  • Glucocorticoid receptors
  • Human glioblastoma cell line

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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