Abstract
In this paper we investigated the lymphoproliferative and cytotoxic responses of peripheral blood mononuclear cells (PBMC) of patients affected with lymphoproliferative disease of granular lymphocytes of T cell origin to mitogens and antigens. Most patients with lymphoproliferative disease of granular lymphocytes (LDGL) showed a severely impaired PBMC proliferative capacity in response to phytohemagglutinin, anti-CD3 and tetanus toxoid, an impairment that, in the case of anti-CD3 response, appears to be related to a defect of phosphorylation in response to triggering. In contrast, at least 50% of the patients had normal proliferation in response to a mannoprotein fraction purified from Candida albicans. These data suggest that some CD3+ GL from LDGL patients, that usually respond poorly to proliferative stimuli in vitro, can be triggered to perform these functions by candidal antigens.
| Original language | English |
|---|---|
| Pages (from-to) | 65-71 |
| Number of pages | 7 |
| Journal | Acta Haematologica |
| Volume | 98 |
| Issue number | 2 |
| Publication status | Published - Aug 1997 |
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Keywords
- Candida albicans mannoproteins
- Lymphoproliferative disease of granular lymphocytes
- Signal transduction
ASJC Scopus subject areas
- Hematology
Cite this
Proliferative responses to PHA, anti-CD3 and antigens in patients with lymphoproliferative disease of granular lymphocytes. Mannoproteins of Candida albicans induce proliferation and cytotoxicity. / Giovannetti, Antonello; Quinti, Isabella; Rainaldi, Luana; Mauro, Francesca R.; Oliva, Alessandra; Pierdominici, Marina; Ricci, Giovanni; De Rossi, Giulio; Cassone, Antonio; Aiuti, Fernando; Pandolfi, Franco.
In: Acta Haematologica, Vol. 98, No. 2, 08.1997, p. 65-71.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proliferative responses to PHA, anti-CD3 and antigens in patients with lymphoproliferative disease of granular lymphocytes. Mannoproteins of Candida albicans induce proliferation and cytotoxicity
AU - Giovannetti, Antonello
AU - Quinti, Isabella
AU - Rainaldi, Luana
AU - Mauro, Francesca R.
AU - Oliva, Alessandra
AU - Pierdominici, Marina
AU - Ricci, Giovanni
AU - De Rossi, Giulio
AU - Cassone, Antonio
AU - Aiuti, Fernando
AU - Pandolfi, Franco
PY - 1997/8
Y1 - 1997/8
N2 - In this paper we investigated the lymphoproliferative and cytotoxic responses of peripheral blood mononuclear cells (PBMC) of patients affected with lymphoproliferative disease of granular lymphocytes of T cell origin to mitogens and antigens. Most patients with lymphoproliferative disease of granular lymphocytes (LDGL) showed a severely impaired PBMC proliferative capacity in response to phytohemagglutinin, anti-CD3 and tetanus toxoid, an impairment that, in the case of anti-CD3 response, appears to be related to a defect of phosphorylation in response to triggering. In contrast, at least 50% of the patients had normal proliferation in response to a mannoprotein fraction purified from Candida albicans. These data suggest that some CD3+ GL from LDGL patients, that usually respond poorly to proliferative stimuli in vitro, can be triggered to perform these functions by candidal antigens.
AB - In this paper we investigated the lymphoproliferative and cytotoxic responses of peripheral blood mononuclear cells (PBMC) of patients affected with lymphoproliferative disease of granular lymphocytes of T cell origin to mitogens and antigens. Most patients with lymphoproliferative disease of granular lymphocytes (LDGL) showed a severely impaired PBMC proliferative capacity in response to phytohemagglutinin, anti-CD3 and tetanus toxoid, an impairment that, in the case of anti-CD3 response, appears to be related to a defect of phosphorylation in response to triggering. In contrast, at least 50% of the patients had normal proliferation in response to a mannoprotein fraction purified from Candida albicans. These data suggest that some CD3+ GL from LDGL patients, that usually respond poorly to proliferative stimuli in vitro, can be triggered to perform these functions by candidal antigens.
KW - Candida albicans mannoproteins
KW - Lymphoproliferative disease of granular lymphocytes
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=0030794562&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030794562&partnerID=8YFLogxK
M3 - Article
C2 - 9286301
AN - SCOPUS:0030794562
VL - 98
SP - 65
EP - 71
JO - Acta Haematologica
JF - Acta Haematologica
SN - 0001-5792
IS - 2
ER -