Proliferative responses to PHA, anti-CD3 and antigens in patients with lymphoproliferative disease of granular lymphocytes. Mannoproteins of Candida albicans induce proliferation and cytotoxicity

Antonello Giovannetti, Isabella Quinti, Luana Rainaldi, Francesca R. Mauro, Alessandra Oliva, Marina Pierdominici, Giovanni Ricci, Giulio De Rossi, Antonio Cassone, Fernando Aiuti, Franco Pandolfi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this paper we investigated the lymphoproliferative and cytotoxic responses of peripheral blood mononuclear cells (PBMC) of patients affected with lymphoproliferative disease of granular lymphocytes of T cell origin to mitogens and antigens. Most patients with lymphoproliferative disease of granular lymphocytes (LDGL) showed a severely impaired PBMC proliferative capacity in response to phytohemagglutinin, anti-CD3 and tetanus toxoid, an impairment that, in the case of anti-CD3 response, appears to be related to a defect of phosphorylation in response to triggering. In contrast, at least 50% of the patients had normal proliferation in response to a mannoprotein fraction purified from Candida albicans. These data suggest that some CD3+ GL from LDGL patients, that usually respond poorly to proliferative stimuli in vitro, can be triggered to perform these functions by candidal antigens.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalActa Haematologica
Volume98
Issue number2
Publication statusPublished - Aug 1997

Fingerprint

Large Granular Lymphocytic Leukemia
CD3 Antigens
Candida albicans
Blood Cells
Antigens
Tetanus Toxoid
Phytohemagglutinins
Mitogens
Phosphorylation
T-Lymphocytes
mannoproteins

Keywords

  • Candida albicans mannoproteins
  • Lymphoproliferative disease of granular lymphocytes
  • Signal transduction

ASJC Scopus subject areas

  • Hematology

Cite this

Proliferative responses to PHA, anti-CD3 and antigens in patients with lymphoproliferative disease of granular lymphocytes. Mannoproteins of Candida albicans induce proliferation and cytotoxicity. / Giovannetti, Antonello; Quinti, Isabella; Rainaldi, Luana; Mauro, Francesca R.; Oliva, Alessandra; Pierdominici, Marina; Ricci, Giovanni; De Rossi, Giulio; Cassone, Antonio; Aiuti, Fernando; Pandolfi, Franco.

In: Acta Haematologica, Vol. 98, No. 2, 08.1997, p. 65-71.

Research output: Contribution to journalArticle

Giovannetti, A, Quinti, I, Rainaldi, L, Mauro, FR, Oliva, A, Pierdominici, M, Ricci, G, De Rossi, G, Cassone, A, Aiuti, F & Pandolfi, F 1997, 'Proliferative responses to PHA, anti-CD3 and antigens in patients with lymphoproliferative disease of granular lymphocytes. Mannoproteins of Candida albicans induce proliferation and cytotoxicity', Acta Haematologica, vol. 98, no. 2, pp. 65-71.
Giovannetti, Antonello ; Quinti, Isabella ; Rainaldi, Luana ; Mauro, Francesca R. ; Oliva, Alessandra ; Pierdominici, Marina ; Ricci, Giovanni ; De Rossi, Giulio ; Cassone, Antonio ; Aiuti, Fernando ; Pandolfi, Franco. / Proliferative responses to PHA, anti-CD3 and antigens in patients with lymphoproliferative disease of granular lymphocytes. Mannoproteins of Candida albicans induce proliferation and cytotoxicity. In: Acta Haematologica. 1997 ; Vol. 98, No. 2. pp. 65-71.
@article{b0ac99616c8642d1b103cd2197307c17,
title = "Proliferative responses to PHA, anti-CD3 and antigens in patients with lymphoproliferative disease of granular lymphocytes. Mannoproteins of Candida albicans induce proliferation and cytotoxicity",
abstract = "In this paper we investigated the lymphoproliferative and cytotoxic responses of peripheral blood mononuclear cells (PBMC) of patients affected with lymphoproliferative disease of granular lymphocytes of T cell origin to mitogens and antigens. Most patients with lymphoproliferative disease of granular lymphocytes (LDGL) showed a severely impaired PBMC proliferative capacity in response to phytohemagglutinin, anti-CD3 and tetanus toxoid, an impairment that, in the case of anti-CD3 response, appears to be related to a defect of phosphorylation in response to triggering. In contrast, at least 50{\%} of the patients had normal proliferation in response to a mannoprotein fraction purified from Candida albicans. These data suggest that some CD3+ GL from LDGL patients, that usually respond poorly to proliferative stimuli in vitro, can be triggered to perform these functions by candidal antigens.",
keywords = "Candida albicans mannoproteins, Lymphoproliferative disease of granular lymphocytes, Signal transduction",
author = "Antonello Giovannetti and Isabella Quinti and Luana Rainaldi and Mauro, {Francesca R.} and Alessandra Oliva and Marina Pierdominici and Giovanni Ricci and {De Rossi}, Giulio and Antonio Cassone and Fernando Aiuti and Franco Pandolfi",
year = "1997",
month = "8",
language = "English",
volume = "98",
pages = "65--71",
journal = "Acta Haematologica",
issn = "0001-5792",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Proliferative responses to PHA, anti-CD3 and antigens in patients with lymphoproliferative disease of granular lymphocytes. Mannoproteins of Candida albicans induce proliferation and cytotoxicity

AU - Giovannetti, Antonello

AU - Quinti, Isabella

AU - Rainaldi, Luana

AU - Mauro, Francesca R.

AU - Oliva, Alessandra

AU - Pierdominici, Marina

AU - Ricci, Giovanni

AU - De Rossi, Giulio

AU - Cassone, Antonio

AU - Aiuti, Fernando

AU - Pandolfi, Franco

PY - 1997/8

Y1 - 1997/8

N2 - In this paper we investigated the lymphoproliferative and cytotoxic responses of peripheral blood mononuclear cells (PBMC) of patients affected with lymphoproliferative disease of granular lymphocytes of T cell origin to mitogens and antigens. Most patients with lymphoproliferative disease of granular lymphocytes (LDGL) showed a severely impaired PBMC proliferative capacity in response to phytohemagglutinin, anti-CD3 and tetanus toxoid, an impairment that, in the case of anti-CD3 response, appears to be related to a defect of phosphorylation in response to triggering. In contrast, at least 50% of the patients had normal proliferation in response to a mannoprotein fraction purified from Candida albicans. These data suggest that some CD3+ GL from LDGL patients, that usually respond poorly to proliferative stimuli in vitro, can be triggered to perform these functions by candidal antigens.

AB - In this paper we investigated the lymphoproliferative and cytotoxic responses of peripheral blood mononuclear cells (PBMC) of patients affected with lymphoproliferative disease of granular lymphocytes of T cell origin to mitogens and antigens. Most patients with lymphoproliferative disease of granular lymphocytes (LDGL) showed a severely impaired PBMC proliferative capacity in response to phytohemagglutinin, anti-CD3 and tetanus toxoid, an impairment that, in the case of anti-CD3 response, appears to be related to a defect of phosphorylation in response to triggering. In contrast, at least 50% of the patients had normal proliferation in response to a mannoprotein fraction purified from Candida albicans. These data suggest that some CD3+ GL from LDGL patients, that usually respond poorly to proliferative stimuli in vitro, can be triggered to perform these functions by candidal antigens.

KW - Candida albicans mannoproteins

KW - Lymphoproliferative disease of granular lymphocytes

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=0030794562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030794562&partnerID=8YFLogxK

M3 - Article

C2 - 9286301

AN - SCOPUS:0030794562

VL - 98

SP - 65

EP - 71

JO - Acta Haematologica

JF - Acta Haematologica

SN - 0001-5792

IS - 2

ER -