Proliferative senescence in hematopoietic stem cells during ex-vivo expansion

Wanda Piacibello, Loretta Gammaitoni, Ymera Pignochino

Research output: Contribution to journalArticle

Abstract

The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalFolia Histochemica et Cytobiologica
Volume43
Issue number4
Publication statusPublished - 2005

Keywords

  • Cell sensecence
  • Ex vivo expansion
  • Hematopoietic stem cells
  • NOD/SCID mice
  • Telomere shortening
  • Transplantation

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy

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