Prolongation by warfarin of 'template' bleeding time in rats: A vitamin K-dependent effect

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Administration of warfarin to rats induced not only the well-known anticoagulant effect, but also an impairment of primary hemostasis as reflected by a significant prolongation of the 'template' bleeding time. This effect was very closely associated with lowering of the prothrombin complex level and was reversed by administration of vitamin K. It is suggested that some of the clotting factors known to be vitamin K-dependent also play a role in primary hemostasis; alternatively, a putative vascular 'bleeding factor' could be modulated by vitamin K availability.

Original languageEnglish
Pages (from-to)275-276
Number of pages2
JournalProceedings of the Society for Experimental Biology and Medicine
Volume181
Issue number2
Publication statusPublished - 1986

Fingerprint

Bleeding Time
Vitamin K
Warfarin
Rats
Hemostasis
Blood Coagulation Factors
Prothrombin
Anticoagulants
Availability
Hemorrhage

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{ad956564af42481c8eedacc5cc95c386,
title = "Prolongation by warfarin of 'template' bleeding time in rats: A vitamin K-dependent effect",
abstract = "Administration of warfarin to rats induced not only the well-known anticoagulant effect, but also an impairment of primary hemostasis as reflected by a significant prolongation of the 'template' bleeding time. This effect was very closely associated with lowering of the prothrombin complex level and was reversed by administration of vitamin K. It is suggested that some of the clotting factors known to be vitamin K-dependent also play a role in primary hemostasis; alternatively, a putative vascular 'bleeding factor' could be modulated by vitamin K availability.",
author = "I. Reyers and {De Gaetano}, G. and Donati, {M. B.}",
year = "1986",
language = "English",
volume = "181",
pages = "275--276",
journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",
issn = "0037-9727",
publisher = "SAGE Publications Ltd",
number = "2",

}

TY - JOUR

T1 - Prolongation by warfarin of 'template' bleeding time in rats

T2 - A vitamin K-dependent effect

AU - Reyers, I.

AU - De Gaetano, G.

AU - Donati, M. B.

PY - 1986

Y1 - 1986

N2 - Administration of warfarin to rats induced not only the well-known anticoagulant effect, but also an impairment of primary hemostasis as reflected by a significant prolongation of the 'template' bleeding time. This effect was very closely associated with lowering of the prothrombin complex level and was reversed by administration of vitamin K. It is suggested that some of the clotting factors known to be vitamin K-dependent also play a role in primary hemostasis; alternatively, a putative vascular 'bleeding factor' could be modulated by vitamin K availability.

AB - Administration of warfarin to rats induced not only the well-known anticoagulant effect, but also an impairment of primary hemostasis as reflected by a significant prolongation of the 'template' bleeding time. This effect was very closely associated with lowering of the prothrombin complex level and was reversed by administration of vitamin K. It is suggested that some of the clotting factors known to be vitamin K-dependent also play a role in primary hemostasis; alternatively, a putative vascular 'bleeding factor' could be modulated by vitamin K availability.

UR - http://www.scopus.com/inward/record.url?scp=0022624779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022624779&partnerID=8YFLogxK

M3 - Article

C2 - 3945636

AN - SCOPUS:0022624779

VL - 181

SP - 275

EP - 276

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 0037-9727

IS - 2

ER -