Prolonged complete remission after induction chemotherapy followed by chemoradiation with tomotherapy in metastatic nasopharyngeal cancer

Dario Agnese, Liliana Belgioia, Almalina Bacigalupo, Michela Marcenaro, Stefania Vecchio, Stefano Agostinelli, Silvia Morbelli, Renzo Corvò

Research output: Contribution to journalArticle

Abstract

Background: Nasopharyngeal carcinoma (NPC) is uncommon in the Western hemisphere and in Europe. The undifferentiated subtype has a relevant propensity to metastasize systemically, mostly in the skeleton. In patients with distant metastasis at presentation there is no consensus on the most appropriate approach. Case Report: Evaluation of a young patient with initially bony metastatic nasopharyngeal cancer treated with platinum-based induction chemotherapy followed by radiotherapy (performed with Tomotherapy) combined to chemotherapy on primary region with curative intent, and subsequent focal irradiation of the bone metastasis. Conclusion: After 27 months from the end of the planned treatment the patient has not shown any late toxicity or complications in the treated areas and is without any evidence of progression. It seems appropriate to treat selected metastatic patients with a radical intent, using induction chemotherapy followed by radical chemoradiotherapy on the primary region and high dose radiation on the metastasis. Moreover, Tomotherapy demonstrated a tolerable grade of acute toxicity without any relevant late complications.

Original languageEnglish
Pages (from-to)5075-5078
Number of pages4
JournalAnticancer Research
Volume34
Issue number9
Publication statusPublished - Sep 1 2014

Keywords

  • Chemoradiation
  • Nasopharyngeal cancer
  • Synchronous metastasis
  • Tomotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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