TY - JOUR
T1 - Prolonged distal motor latency of median nerve does not improve diagnostic accuracy for CIDP
AU - Spina, Emanuele
AU - Doneddu, Pietro Emiliano
AU - Liberatore, Giuseppe
AU - Cocito, Dario
AU - Fazio, Raffaella
AU - Briani, Chiara
AU - Filosto, Massimiliano
AU - Benedetti, Luana
AU - Antonini, Giovanni
AU - Cosentino, Giuseppe
AU - Jann, Stefano
AU - Mazzeo, Anna
AU - Cortese, Andrea
AU - Marfia, Girolama Alessandra
AU - Clerici, Angelo Maurizio
AU - Siciliano, Gabriele
AU - Carpo, Marinella
AU - Luigetti, Marco
AU - Lauria, Giuseppe
AU - Rosso, Tiziana
AU - Cavaletti, Guido
AU - Peci, Erdita
AU - Tronci, Stefano
AU - Ruiz, Marta
AU - Piccinelli, Stefano Cotti
AU - Schenone, Angelo
AU - Leonardi, Luca
AU - Gentile, Luca
AU - Piccolo, Laura
AU - Mataluni, Giorgia
AU - Santoro, Lucio
AU - Nobile-Orazio, Eduardo
AU - Manganelli, Fiore
PY - 2022
Y1 - 2022
N2 - Compression of the median nerve at the carpal tunnel can give demyelinating features and result in distal motor latency (DML) prolongation fulfilling the EFNS/PNS demyelinating criteria for chronic inflammatory demyelinating polyneuropathy (CIDP). Accordingly, being carpal tunnel syndrome (CTS) common in the general population, the EFNS/PNS guidelines recommend excluding the DML of the median nerve when DML prolongation may be consistent with median neuropathy at the wrist from CTS. The main aims of this study were to verify whether the inclusion of DML of the median nerve (when consistent with CTS) could improve electrophysiological diagnostic accuracy for CIDP and if the median nerve at the carpal tunnel was more prone to demyelination. We analyzed electrophysiological data from 499 patients included consecutively into the Italian CIDP Database. According to the EFNS/PNS criteria, 352 patients had a definite, 10 a probable, and 57 a possible diagnosis of CIDP, while 80 were not fulfilling the diagnostic criteria. The inclusion of DML prolongation of median nerve did not improve significantly the diagnostic accuracy for CIDP; overall diagnostic class changed in 6 out of 499 patients (1.2%) and electrodiagnostic class of CIDP changed from not fulfilling to possible in only 2 patients (2.5% of not-fulfilling patients). In conclusion, we can infer that excluding DML prolongation of median nerve does not increase the risk of missing a diagnosis of CIDP thus corroborating the current EFNS/PNS criteria.
AB - Compression of the median nerve at the carpal tunnel can give demyelinating features and result in distal motor latency (DML) prolongation fulfilling the EFNS/PNS demyelinating criteria for chronic inflammatory demyelinating polyneuropathy (CIDP). Accordingly, being carpal tunnel syndrome (CTS) common in the general population, the EFNS/PNS guidelines recommend excluding the DML of the median nerve when DML prolongation may be consistent with median neuropathy at the wrist from CTS. The main aims of this study were to verify whether the inclusion of DML of the median nerve (when consistent with CTS) could improve electrophysiological diagnostic accuracy for CIDP and if the median nerve at the carpal tunnel was more prone to demyelination. We analyzed electrophysiological data from 499 patients included consecutively into the Italian CIDP Database. According to the EFNS/PNS criteria, 352 patients had a definite, 10 a probable, and 57 a possible diagnosis of CIDP, while 80 were not fulfilling the diagnostic criteria. The inclusion of DML prolongation of median nerve did not improve significantly the diagnostic accuracy for CIDP; overall diagnostic class changed in 6 out of 499 patients (1.2%) and electrodiagnostic class of CIDP changed from not fulfilling to possible in only 2 patients (2.5% of not-fulfilling patients). In conclusion, we can infer that excluding DML prolongation of median nerve does not increase the risk of missing a diagnosis of CIDP thus corroborating the current EFNS/PNS criteria.
U2 - 10.1007/s00415-021-10672-w
DO - 10.1007/s00415-021-10672-w
M3 - Article
C2 - 34173874
JO - J. Neurol.
JF - J. Neurol.
SN - 1432-1459
ER -