TY - JOUR
T1 - Prolonged Drainage and Intrapericardial Bleomycin Administration for Cardiac Tamponade Secondary to Cancer-Related Pericardial Effusion
AU - Numico, Gianmauro
AU - Cristofano, Antonella
AU - Occelli, Marcella
AU - Sicuro, Marco
AU - Mozzicafreddo, Alessandro
AU - Fea, Elena
AU - Colantonio, Ida
AU - Merlano, Marco
AU - Piovano, Pierluigi
AU - Silvestris, Nicola
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Malignant pericardial effusion (MPE) is a serious complication of several cancers. The most commonly involved solid tumors are lung and breast cancer. MPE can give rise to the clinical picture of cardiac tamponade, a life threatening condition that needs immediate drainage. While simple pericardiocentesis allows resolution of the symptoms, MPE frequently relapses unless further procedures are performed. Prolonged drainage, talcage with antineoplastic agents, or surgical creation of a pleuro-pericardial window are the most commonly suggested ones. They all result in MPE resolution and high rates of long-term control. Patients suitable for further systemic treatments can have a good prognosis irrespective of the pericardial site of disease. We prospectively enrolled patients with cardiac tamponade treated with prolonged drainage associated with Bleomycin administration. Twenty-two consecutive patients with MPE and associated signs of hemodynamical compromise underwent prolonged drainage and subsequent Bleomycin administration. After injection of 100mg lidocaine hydrochloride, 10mg Bleomycin was injected into the pericardial space. The catheter was clumped for 48h and then reopened. Removal was performed when the drainage volume was
AB - Malignant pericardial effusion (MPE) is a serious complication of several cancers. The most commonly involved solid tumors are lung and breast cancer. MPE can give rise to the clinical picture of cardiac tamponade, a life threatening condition that needs immediate drainage. While simple pericardiocentesis allows resolution of the symptoms, MPE frequently relapses unless further procedures are performed. Prolonged drainage, talcage with antineoplastic agents, or surgical creation of a pleuro-pericardial window are the most commonly suggested ones. They all result in MPE resolution and high rates of long-term control. Patients suitable for further systemic treatments can have a good prognosis irrespective of the pericardial site of disease. We prospectively enrolled patients with cardiac tamponade treated with prolonged drainage associated with Bleomycin administration. Twenty-two consecutive patients with MPE and associated signs of hemodynamical compromise underwent prolonged drainage and subsequent Bleomycin administration. After injection of 100mg lidocaine hydrochloride, 10mg Bleomycin was injected into the pericardial space. The catheter was clumped for 48h and then reopened. Removal was performed when the drainage volume was
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U2 - 10.1097/MD.0000000000003273
DO - 10.1097/MD.0000000000003273
M3 - Article
AN - SCOPUS:84964584208
VL - 95
JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries
SN - 0025-7974
IS - 15
M1 - e3273
ER -