Prolonged duration of myocardial ischemia in patients with coronary heart disease and impaired cardiopulmonary baroreceptor sensitivity

Bruno Trimarco, Sergio Chierchia, Giuseppe Lembo, Nicola De Luca, Bruno Ricciardelli, Gianluigi Condorelli, Massimo Volpe, Mario Condorelli

Research output: Contribution to journalArticle

Abstract

To investigate the potential contribution of cardiopulmonary reflexes in myocardial ischemia, the coronary vascular response to cardiopulmonary baroreceptor unloading and the number and the duration of spontaneous episodes of symptomatic and asymptomatic myocardial ischemia were evaluated in 23 patients with coronary heart disease. Lower-body negative pressure at -10 mm Hg, which causes selective deactivation of cardiopulmonary receptors, reduced left ventricular filling pressure in all patients, but calculated coronary vascular resistance increased in only 14 patients (from 0.846±0.1 to 1.07±0.1 mm Hg/ml/min,/p

Original languageEnglish
Pages (from-to)1792-1802
Number of pages11
JournalCirculation
Volume81
Issue number6
Publication statusPublished - 1990

Keywords

  • Coronary heart disease
  • Digitalis
  • Myocardial ischemia
  • Ventricular receptors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Trimarco, B., Chierchia, S., Lembo, G., De Luca, N., Ricciardelli, B., Condorelli, G., Volpe, M., & Condorelli, M. (1990). Prolonged duration of myocardial ischemia in patients with coronary heart disease and impaired cardiopulmonary baroreceptor sensitivity. Circulation, 81(6), 1792-1802.