Prolonged molecular remission in advanced acute promyelocytic leukaemia after treatment with gemtuzumab ozogamicin (Mylotarg™ CMA-676)

Maria C. Petti, Maria B. Pinazzi, Daniela Diverio, Atelda Romano, Maria T. Petrucci, Silvia De Santis, Giovanna Meloni, Agostino Tafuri, Franco Mandelli, Francesco Lo Coco

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

We report a patient with acute promyelocytic leukaemia (APL) who received two doses of gemtuzumab ozogamicin for advanced disease. Previous treatments included front-line all-trans retinoic acid and anthracyclines, polychemotherapy consolidation, salvage chemotherapy for the first relapse followed by autologous stem cell transplantation (ASCT), arsenic trioxide for the second relapse followed by a second ASCT and then high-dose methotrexate for more advanced systemic disease with central nervous system involvement. The patient achieved prolonged haematological and molecular remission after monotherapy with gemtuzumab ozogamicin given at the time of the third relapse.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalBritish Journal of Haematology
Volume115
Issue number1
DOIs
Publication statusPublished - 2001

Fingerprint

Acute Promyelocytic Leukemia
Stem Cell Transplantation
Recurrence
Consolidation Chemotherapy
Anthracyclines
Central Nervous System Diseases
Tretinoin
Combination Drug Therapy
Methotrexate
Therapeutics
gemtuzumab

Keywords

  • Acute promyelocytic
  • CD33
  • Gemtuzumab ozogamicin
  • Leukaemia
  • Molecular remission
  • PML/RARα

ASJC Scopus subject areas

  • Hematology

Cite this

Prolonged molecular remission in advanced acute promyelocytic leukaemia after treatment with gemtuzumab ozogamicin (Mylotarg™ CMA-676). / Petti, Maria C.; Pinazzi, Maria B.; Diverio, Daniela; Romano, Atelda; Petrucci, Maria T.; De Santis, Silvia; Meloni, Giovanna; Tafuri, Agostino; Mandelli, Franco; Lo Coco, Francesco.

In: British Journal of Haematology, Vol. 115, No. 1, 2001, p. 63-65.

Research output: Contribution to journalArticle

Petti, Maria C. ; Pinazzi, Maria B. ; Diverio, Daniela ; Romano, Atelda ; Petrucci, Maria T. ; De Santis, Silvia ; Meloni, Giovanna ; Tafuri, Agostino ; Mandelli, Franco ; Lo Coco, Francesco. / Prolonged molecular remission in advanced acute promyelocytic leukaemia after treatment with gemtuzumab ozogamicin (Mylotarg™ CMA-676). In: British Journal of Haematology. 2001 ; Vol. 115, No. 1. pp. 63-65.
@article{6bca82a757344541ab63bac62e7a3e26,
title = "Prolonged molecular remission in advanced acute promyelocytic leukaemia after treatment with gemtuzumab ozogamicin (Mylotarg™ CMA-676)",
abstract = "We report a patient with acute promyelocytic leukaemia (APL) who received two doses of gemtuzumab ozogamicin for advanced disease. Previous treatments included front-line all-trans retinoic acid and anthracyclines, polychemotherapy consolidation, salvage chemotherapy for the first relapse followed by autologous stem cell transplantation (ASCT), arsenic trioxide for the second relapse followed by a second ASCT and then high-dose methotrexate for more advanced systemic disease with central nervous system involvement. The patient achieved prolonged haematological and molecular remission after monotherapy with gemtuzumab ozogamicin given at the time of the third relapse.",
keywords = "Acute promyelocytic, CD33, Gemtuzumab ozogamicin, Leukaemia, Molecular remission, PML/RARα",
author = "Petti, {Maria C.} and Pinazzi, {Maria B.} and Daniela Diverio and Atelda Romano and Petrucci, {Maria T.} and {De Santis}, Silvia and Giovanna Meloni and Agostino Tafuri and Franco Mandelli and {Lo Coco}, Francesco",
year = "2001",
doi = "10.1046/j.1365-2141.2001.03091.x",
language = "English",
volume = "115",
pages = "63--65",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "1",

}

TY - JOUR

T1 - Prolonged molecular remission in advanced acute promyelocytic leukaemia after treatment with gemtuzumab ozogamicin (Mylotarg™ CMA-676)

AU - Petti, Maria C.

AU - Pinazzi, Maria B.

AU - Diverio, Daniela

AU - Romano, Atelda

AU - Petrucci, Maria T.

AU - De Santis, Silvia

AU - Meloni, Giovanna

AU - Tafuri, Agostino

AU - Mandelli, Franco

AU - Lo Coco, Francesco

PY - 2001

Y1 - 2001

N2 - We report a patient with acute promyelocytic leukaemia (APL) who received two doses of gemtuzumab ozogamicin for advanced disease. Previous treatments included front-line all-trans retinoic acid and anthracyclines, polychemotherapy consolidation, salvage chemotherapy for the first relapse followed by autologous stem cell transplantation (ASCT), arsenic trioxide for the second relapse followed by a second ASCT and then high-dose methotrexate for more advanced systemic disease with central nervous system involvement. The patient achieved prolonged haematological and molecular remission after monotherapy with gemtuzumab ozogamicin given at the time of the third relapse.

AB - We report a patient with acute promyelocytic leukaemia (APL) who received two doses of gemtuzumab ozogamicin for advanced disease. Previous treatments included front-line all-trans retinoic acid and anthracyclines, polychemotherapy consolidation, salvage chemotherapy for the first relapse followed by autologous stem cell transplantation (ASCT), arsenic trioxide for the second relapse followed by a second ASCT and then high-dose methotrexate for more advanced systemic disease with central nervous system involvement. The patient achieved prolonged haematological and molecular remission after monotherapy with gemtuzumab ozogamicin given at the time of the third relapse.

KW - Acute promyelocytic

KW - CD33

KW - Gemtuzumab ozogamicin

KW - Leukaemia

KW - Molecular remission

KW - PML/RARα

UR - http://www.scopus.com/inward/record.url?scp=0034773130&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034773130&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.2001.03091.x

DO - 10.1046/j.1365-2141.2001.03091.x

M3 - Article

VL - 115

SP - 63

EP - 65

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 1

ER -