Abstract
Atypical adenomatous hyperplasia (AAH) is a putative precursor of bronchioloalveolar carcinoma (BAC) and adenocarcinoma of the lung, developing from terminal respiratory unit cells. AAH and BAC lesions typically present as ground-glass opacities at spiral chest computed tomography. Epidermal growth factor receptor polysomy/mutations, conferring higher sensitivity to Gefitinib, are frequent in BAC but less common in AAH. We describe an interesting case of disseminated AAH showing a sustained remission under Gefitinib therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 266-267 |
| Number of pages | 2 |
| Journal | Journal of Thoracic Oncology |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2009 |
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Keywords
- AAH
- BAC
- CT screening
- FISH
- Gefitinib
ASJC Scopus subject areas
- Oncology
- Pulmonary and Respiratory Medicine
- Medicine(all)
Cite this
Prolonged remission of disseminated atypical adenomatous hyperplasia under gefitinib. / Pastorino, Ugo; Calabrò, Elisa; Tamborini, Elena; Marchianò, Alfonso; Orsenigo, Marta; Fabbri, Alessandra; Sozzi, Gabriella; Novello, Silvia; De Marinis, Filippo.
In: Journal of Thoracic Oncology, Vol. 4, No. 2, 02.2009, p. 266-267.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prolonged remission of disseminated atypical adenomatous hyperplasia under gefitinib
AU - Pastorino, Ugo
AU - Calabrò, Elisa
AU - Tamborini, Elena
AU - Marchianò, Alfonso
AU - Orsenigo, Marta
AU - Fabbri, Alessandra
AU - Sozzi, Gabriella
AU - Novello, Silvia
AU - De Marinis, Filippo
PY - 2009/2
Y1 - 2009/2
N2 - Atypical adenomatous hyperplasia (AAH) is a putative precursor of bronchioloalveolar carcinoma (BAC) and adenocarcinoma of the lung, developing from terminal respiratory unit cells. AAH and BAC lesions typically present as ground-glass opacities at spiral chest computed tomography. Epidermal growth factor receptor polysomy/mutations, conferring higher sensitivity to Gefitinib, are frequent in BAC but less common in AAH. We describe an interesting case of disseminated AAH showing a sustained remission under Gefitinib therapy.
AB - Atypical adenomatous hyperplasia (AAH) is a putative precursor of bronchioloalveolar carcinoma (BAC) and adenocarcinoma of the lung, developing from terminal respiratory unit cells. AAH and BAC lesions typically present as ground-glass opacities at spiral chest computed tomography. Epidermal growth factor receptor polysomy/mutations, conferring higher sensitivity to Gefitinib, are frequent in BAC but less common in AAH. We describe an interesting case of disseminated AAH showing a sustained remission under Gefitinib therapy.
KW - AAH
KW - BAC
KW - CT screening
KW - FISH
KW - Gefitinib
UR - http://www.scopus.com/inward/record.url?scp=65649092654&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65649092654&partnerID=8YFLogxK
U2 - 10.1097/JTO.0b013e3181952930
DO - 10.1097/JTO.0b013e3181952930
M3 - Article
C2 - 19179908
AN - SCOPUS:65649092654
VL - 4
SP - 266
EP - 267
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
SN - 1556-0864
IS - 2
ER -