Prolonged remission of disseminated atypical adenomatous hyperplasia under gefitinib

Research output: Contribution to journalArticle

Abstract

Atypical adenomatous hyperplasia (AAH) is a putative precursor of bronchioloalveolar carcinoma (BAC) and adenocarcinoma of the lung, developing from terminal respiratory unit cells. AAH and BAC lesions typically present as ground-glass opacities at spiral chest computed tomography. Epidermal growth factor receptor polysomy/mutations, conferring higher sensitivity to Gefitinib, are frequent in BAC but less common in AAH. We describe an interesting case of disseminated AAH showing a sustained remission under Gefitinib therapy.

Original languageEnglish
Pages (from-to)266-267
Number of pages2
JournalJournal of Thoracic Oncology
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 2009

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Bronchiolo-Alveolar Adenocarcinoma
Hyperplasia
Spiral Computed Tomography
Epidermal Growth Factor Receptor
Glass
Thorax
Mutation
gefitinib
Therapeutics

Keywords

  • AAH
  • BAC
  • CT screening
  • FISH
  • Gefitinib

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

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abstract = "Atypical adenomatous hyperplasia (AAH) is a putative precursor of bronchioloalveolar carcinoma (BAC) and adenocarcinoma of the lung, developing from terminal respiratory unit cells. AAH and BAC lesions typically present as ground-glass opacities at spiral chest computed tomography. Epidermal growth factor receptor polysomy/mutations, conferring higher sensitivity to Gefitinib, are frequent in BAC but less common in AAH. We describe an interesting case of disseminated AAH showing a sustained remission under Gefitinib therapy.",
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author = "Ugo Pastorino and Elisa Calabr{\`o} and Elena Tamborini and Alfonso Marchian{\`o} and Marta Orsenigo and Alessandra Fabbri and Gabriella Sozzi and Silvia Novello and {De Marinis}, Filippo",
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AU - Pastorino, Ugo

AU - Calabrò, Elisa

AU - Tamborini, Elena

AU - Marchianò, Alfonso

AU - Orsenigo, Marta

AU - Fabbri, Alessandra

AU - Sozzi, Gabriella

AU - Novello, Silvia

AU - De Marinis, Filippo

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