Prolonged treatment (one year) of histologically advanced chronic hepatitis C with recombinant interferon alpha

R. Cozzolongo, R. Cuppone, F. Ragnini, V. Guglielmi, F. Rosina, O. G. Manghisi

Research output: Contribution to journalArticlepeer-review

Abstract

Standard recombinant interferon α (rIFN-α) therapy induces a sustained ALT normalization in 15% to 25% of patients with chronic hepatitis C. In cirrhotic patients this rate of response is still lower. We evaluated if a longer duration of treatment (12 months) might increase this disappointing response rate and if the clinical characteristics of patients could differentiate responders from nonresponders in a population where liver cirrhosis was prevalent. At the end-of-treatment period, the rate of ALT normalization was 29%. After 12 months of a follow-up period, only 10% of treated patients had normal ALT and, among cirrhotic patients, this value fell to 4.1%. Only initial low γ-glutamyltranspeptidase levels (GGT) were associated with response to IFN treatment. Our results indicate that a prolonged course of rIFN-α is not able to increase the rate of durable response to IFN in patients with advanced chronic hepatitis C.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalMediterranean Journal of Infectious and Parasitic Diseases
Volume11
Issue number2
Publication statusPublished - 1996

Keywords

  • antiviral therapy
  • chronic hepatitis C
  • interferon

ASJC Scopus subject areas

  • Microbiology (medical)

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